Leucine-rich repeat-containing protein 3 (LRRC3)

About Leucine-rich repeat-containing protein 3

Leucine-rich repeat-containing protein 3 (LRRC3) is a protein from Homo sapiens identified by UniProt accession Q9BY71, 257 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.

Target properties

Protein name	Leucine-rich repeat-containing protein 3
UniProt accession	Q9BY71
Gene	LRRC3
Organism	Homo sapiens
Length	257 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (18)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.23
brain aneurysm · score 0.22
22q11.2 deletion syndrome · score 0.04
hypoparathyroidism, familial isolated, 2 · score 0.04
pseudohypoparathyroidism type 2 · score 0.03
Familial isolated hypoparathyroidism · score 0.03
metabolite measurement · score 0.02
Wilson disease · score 0.01
cancer · score 0.00
Intestinal epithelial dysplasia · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BY71-F1	alphafold	PREDICTED	82.98	—

Amino-acid sequence (257 residues)

MGTVRPPRPS LLLVSTRESC LFLLFCLHLG AACPQPCRCP DHAGAVAVFC SLRGLQEVPE DIPANTVLLK LDANKISHLP DGAFQHLHRL RELDLSHNAI EAIGSATFAG LAGGLRLLDL SYNRIQRIPK DALGKLSAKI RLSHNPLHCE CALQEALWEL KLDPDSVDEI ACHTSVQEEF VGKPLVQALD AGASLCSVPH RTTDVAMLVT MFGWFAMVIA YVVYYVRHNQ EDARRHLEYL KSLPSAPASK DPIGPGP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards