Angiopoietin-related protein 4 (ANGPTL4)

About Angiopoietin-related protein 4

Angiopoietin-related protein 4 (ANGPTL4) is a protein from Homo sapiens identified by UniProt accession Q9BY76, 406 residues long. MolForge cross-references it against 0 known binders and 469 disease associations.

Target properties

Protein name	Angiopoietin-related protein 4
UniProt accession	Q9BY76
Gene	ANGPTL4
Organism	Homo sapiens
Length	406 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (469)

Diseases linked to this target (Open Targets).

triglyceride measurement · score 0.70
high density lipoprotein cholesterol measurement · score 0.62
triglycerides:total lipids ratio · score 0.54
sphingomyelin measurement · score 0.38
reticulocyte count · score 0.37
Red cell distribution width · score 0.37
phosphatidylcholine measurement · score 0.35
mean corpuscular volume · score 0.35
apolipoprotein A 1 measurement · score 0.34
coronary artery disease · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BY76-F1	alphafold	PREDICTED	78.00	—

Amino-acid sequence (406 residues)

MSGAPTAGAA LMLCAATAVL LSAQGGPVQS KSPRFASWDE MNVLAHGLLQ LGQGLREHAE RTRSQLSALE RRLSACGSAC QGTEGSTDLP LAPESRVDPE VLHSLQTQLK AQNSRIQQLF HKVAQQQRHL EKQHLRIQHL QSQFGLLDHK HLDHEVAKPA RRKRLPEMAQ PVDPAHNVSR LHRLPRDCQE LFQVGERQSG LFEIQPQGSP PFLVNCKMTS DGGWTVIQRR HDGSVDFNRP WEAYKAGFGD PHGEFWLGLE KVHSITGDRN SRLAVQLRDW DGNAELLQFS VHLGGEDTAY SLQLTAPVAG QLGATTVPPS GLSVPFSTWD QDHDLRRDKN CAKSLSGGWW FGTCSHSNLN GQYFRSIPQQ RQKLKKGIFW KTWRGRYYPL QATTMLIQPM AAEAAS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards