E3 ubiquitin-protein ligase RNF26 (RNF26)

About E3 ubiquitin-protein ligase RNF26

E3 ubiquitin-protein ligase RNF26 (RNF26) is a protein from Homo sapiens identified by UniProt accession Q9BY78, 433 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase RNF26
UniProt accession	Q9BY78
Gene	RNF26
Organism	Homo sapiens
Length	433 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (28)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.34
blood protein measurement · score 0.27
platelet crit · score 0.20
urinary bladder carcinoma · score 0.07
platelet count · score 0.07
viral disease · score 0.05
mean corpuscular hemoglobin concentration · score 0.03
nonpapillary renal cell carcinoma · score 0.03
stomach neoplasm · score 0.03
cancer · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BY78-F1	alphafold	PREDICTED	75.04	—

Amino-acid sequence (433 residues)

MEAVYLVVNG LGLVLDVLTL VLDLNFLLVS SLLASLAWLL AFVYNLPHTV LTSLLHLGRG VLLSLLALIE AVVRFTCGGL QALCTLLYSC CSGLESLKLL GHLASHGALR SREILHRGVL NVVSSGHALL RQACDICAIA MSLVAYVINS LVNICLIGTQ NLFSLVLALW DAVTGPLWRM TDVVAAFLAH ISSSAVAMAI LLWTPCQLAL ELLASAARLL ASFVLVNLTG LVLLACVLAV TVTVLHPDFT LRLATQALSQ LHARPSYHRL REDVMRLSRL ALGSEAWRRV WSRSLQLASW PNRGGAPGAP QGDPMRVFSV RTRRQDTLPE AGRRSEAEEE EARTIRVTPV RGRERLNEEE PPGGQDPWKL LKEQEERKKC VICQDQSKTV LLLPCRHLCL CQACTEILMR HPVYHRNCPL CRRGILQTLN VYL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards