About Membrane frizzled-related protein
Membrane frizzled-related protein (MFRP) is a protein
from Homo sapiens identified by UniProt accession
Q9BY79, 579 residues long.
MolForge cross-references it against 0 known binders and
171 disease associations.
Target properties
| Protein name | Membrane frizzled-related protein |
|---|
| UniProt accession | Q9BY79 |
|---|
| Gene | MFRP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 579 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (171)
Diseases linked to this target (Open Targets).
- isolated microphthalmia 5 · score 0.74
- nanophthalmos 2 · score 0.73
- Microphthalmia - retinitis pigmentosa - foveoschisis - optic disc drusen · score 0.66
- late-onset retinal degeneration · score 0.51
- Retinal dystrophy · score 0.50
- eye measurement · score 0.48
- isolated microphthalmia · score 0.46
- nanophthalmia · score 0.44
- refractive error measurement · score 0.28
- urate measurement · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BY79-F1 | alphafold | PREDICTED | 72.53 | — |
Amino-acid sequence (579 residues)
MKDFSDVILC MEATESSKTE FCNPAFEPES GPPCPPPVFP EDASYSVPAP WHGRRPRGLR PDCRFSWLCV LLLSSLLLLL LGLLVAIILA QLQAAPPSGA SHSPLPAGGL TTTTTTPTIT TSQAAGTPKG QQESGVSPSP QSTCGGLLSG PRGFFSSPNY PDPYPPNTHC VWHIQVATDH AIQLKIEALS IESVASCLFD RLELSPEPEG PLLRVCGRVP PPTLNTNASH LLVVFVSDSS VEGFGFHAWY QAMAPGRGSC AHDEFRCDQL ICLLPDSVCD GFANCADGSD ETNCSAKFSG CGGNLTGLQG TFSTPSYLQQ YPHQLLCTWH ISVPAGHSIE LQFHNFSLEA QDECKFDYVE VYETSSSGAF SLLGRFCGAE PPPHLVSSHH ELAVLFRTDH GISSGGFSAT YLAFNATENP CGPSELSCQA GGCKGVQWMC DMWRDCTDGS DDNCSGPLFP PPELACEPVQ VEMCLGLSYN TTAFPNIWVG MITQEEVVEV LSGYKSLTSL PCYQHFRRLL CGLLVPRCTP LGSVLPPCRS VCQEAEHQCQ SGLALLGTPW PFNCNRLPEA ADLEACAQP
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