Guanine nucleotide-binding protein subunit…

About Guanine nucleotide-binding protein subunit beta-like protein 1

Guanine nucleotide-binding protein subunit beta-like protein 1 (GNB1L) is a protein from Homo sapiens identified by UniProt accession Q9BYB4, 327 residues long. MolForge cross-references it against 0 known binders and 86 disease associations.

Target properties

Protein name	Guanine nucleotide-binding protein subunit beta-like protein 1
UniProt accession	Q9BYB4
Gene	GNB1L
Organism	Homo sapiens
Length	327 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (86)

Diseases linked to this target (Open Targets).

FEV/FVC ratio · score 0.37
PHF-tau measurement · score 0.27
intraocular pressure measurement · score 0.27
open-angle glaucoma · score 0.26
glaucoma · score 0.16
neurofibrillary tangles measurement · score 0.08
age-related macular degeneration · score 0.08
prostate carcinoma · score 0.07
nephrotic syndrome · score 0.07
X-linked retinal dysplasia · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BYB4-F1	alphafold	PREDICTED	91.84	—

Amino-acid sequence (327 residues)

MTAPCPPPPP DPQFVLRGTQ SPVHALHFCE GAQAQGRPLL FSGSQSGLVH IWSLQTRRAV TTLDGHGGQC VTWLQTLPQG RQLLSQGRDL KLCLWDLAEG RSAVVDSVCL ESVGFCRSSI LAGGQPRWTL AVPGRGSDEV QILEMPSKTS VCALKPKADA KLGMPMCLRL WQADCSSRPL LLAGYEDGSV VLWDVSEQKV CSRIACHEEP VMDLDFDSQK ARGISGSAGK ALAVWSLDWQ QALQVRGTHE LTNPGIAEVT IRPDRKILAT AGWDHRIRVF HWRTMQPLAV LAFHSAAVQC VAFTADGLLA AGSKDQRISL WSLYPRA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Guanine nucleotide-binding protein subunit beta-like protein 1 (GNB1L)