About Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial
Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial (OXCT2) is a protein
from Homo sapiens identified by UniProt accession
Q9BYC2, 517 residues long.
MolForge cross-references it against 0 known binders and
22 disease associations.
Target properties
| Protein name | Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial |
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| UniProt accession | Q9BYC2 |
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| Gene | OXCT2 |
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| Organism | Homo sapiens |
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| Length | 517 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (22)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- neuroinflammatory disorder · score 0.35
- diabetes mellitus · score 0.23
- Snoring · score 0.19
- heel bone mineral density · score 0.15
- blood protein measurement · score 0.09
- peptidyl-prolyl cis-trans isomerase E measurement · score 0.07
- appendicular lean mass · score 0.04
- hemorrhoid · score 0.04
- FEV/FVC ratio · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BYC2-F1 | alphafold | PREDICTED | 91.60 | — |
Amino-acid sequence (517 residues)
MAALRLLASV LGRGVPAGGS GLALSQGCAR CFATSPRLRA KFYADPVEMV KDISDGATVM IGGFGLCGIP ENLIAALLRT RVKDLQVVSS NVGVEDFGLG LLLAARQVRR IVCSYVGENT LCESQYLAGE LELELTPQGT LAERIRAGGA GVPAFYTPTG YGTLVQEGGA PIRYTPDGHL ALMSQPREVR EFNGDHFLLE RAIRADFALV KGWKADRAGN VVFRRSARNF NVPMCKAADV TAVEVEEIVE VGAFPPEDIH VPNIYVDRVI KGQKYEKRIE RLTILKEEDG DAGKEEDART RIIRRAALEF EDGMYANLGI GIPLLASNFI SPSMTVHLHS ENGILGLGPF PTEDEVDADL INAGKQTVTV LPGGCFFASD DSFAMIRGGH IQLTMLGAMQ VSKYGDLANW MIPGKKVKGM GGAMDLVSSQ KTRVVVTMQH CTKDNTPKIM EKCTMPLTGK RCVDRIITEK AVFDVHRKKE LTLRELWEGL TVDDIKKSTG CAFAVSPNLR PMQQVAP
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