About Alpha-(1,6)-fucosyltransferase
Alpha-(1,6)-fucosyltransferase (FUT8) is a protein
from Homo sapiens identified by UniProt accession
Q9BYC5, 575 residues long.
MolForge cross-references it against 0 known binders and
172 disease associations.
Target properties
| Protein name | Alpha-(1,6)-fucosyltransferase |
|---|
| UniProt accession | Q9BYC5 |
|---|
| Gene | FUT8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 575 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (172)
Diseases linked to this target (Open Targets).
- congenital disorder of glycosylation with defective fucosylation · score 0.75
- N-glycan measurement · score 0.43
- platelet count · score 0.42
- blood protein measurement · score 0.42
- genetic disorder · score 0.41
- serum IgG glycosylation measurement · score 0.40
- hematocrit · score 0.39
- hemoglobin measurement · score 0.38
- platelet crit · score 0.38
- erythrocyte count · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BYC5-F1 | alphafold | PREDICTED | 91.98 | — |
Amino-acid sequence (575 residues)
MRPWTGSWRW IMLILFAWGT LLFYIGGHLV RDNDHPDHSS RELSKILAKL ERLKQQNEDL RRMAESLRIP EGPIDQGPAI GRVRVLEEQL VKAKEQIENY KKQTRNGLGK DHEILRRRIE NGAKELWFFL QSELKKLKNL EGNELQRHAD EFLLDLGHHE RSIMTDLYYL SQTDGAGDWR EKEAKDLTEL VQRRITYLQN PKDCSKAKKL VCNINKGCGY GCQLHHVVYC FMIAYGTQRT LILESQNWRY ATGGWETVFR PVSETCTDRS GISTGHWSGE VKDKNVQVVE LPIVDSLHPR PPYLPLAVPE DLADRLVRVH GDPAVWWVSQ FVKYLIRPQP WLEKEIEEAT KKLGFKHPVI GVHVRRTDKV GTEAAFHPIE EYMVHVEEHF QLLARRMQVD KKRVYLATDD PSLLKEAKTK YPNYEFISDN SISWSAGLHN RYTENSLRGV ILDIHFLSQA DFLVCTFSSQ VCRVAYEIMQ TLHPDASANF HSLDDIYYFG GQNAHNQIAI YAHQPRTADE IPMEPGDIIG VAGNHWDGYS KGVNRKLGRT GLYPSYKVRE KIETVKYPTY PEAEK
Explore Alpha-(1,6)-fucosyltransferase with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets