Actin-related protein T3 (ACTRT3)

About Actin-related protein T3

Actin-related protein T3 (ACTRT3) is a protein from Homo sapiens identified by UniProt accession Q9BYD9, 372 residues long. MolForge cross-references it against 0 known binders and 74 disease associations.

Target properties

Protein name	Actin-related protein T3
UniProt accession	Q9BYD9
Gene	ACTRT3
Organism	Homo sapiens
Length	372 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (74)

Diseases linked to this target (Open Targets).

dyskeratosis congenita · score 0.55
idiopathic aplastic anemia · score 0.54
Aplastic anemia · score 0.52
interstitial lung disease · score 0.37
systolic blood pressure · score 0.34
sex hormone-binding globulin measurement · score 0.34
paroxysmal nocturnal hemoglobinuria 1 · score 0.33
telomere syndrome · score 0.33
mean corpuscular volume · score 0.32
telomere length · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BYD9-F1	alphafold	PREDICTED	94.38	—

Amino-acid sequence (372 residues)

MNHCQLPVVI DNGSGMIKAG VAGCREPQFI YPNIIGRAKG QSRAAQGGLE LCVGDQAQDW RSSLFISYPV ERGLITSWED MEIMWKHIYD YNLKLKPCDG PVLITEPALN PLANRQQITE MFFEHLGVPA FYMSIQAVLA LFAAGFTTGL VLNSGAGVTQ SVPIFEGYCL PHGVQQLDLA GLDLTNYLMV LMKNHGIMLL SASDRKIVED IKESFCYVAM NYEEEMAKKP DCLEKVYQLP DGKVIQLHDQ LFSCPEALFS PCHMNLEAPG IDKICFSSIM KCDTGLRNSF FSNIILAGGS TSFPGLDKRL VKDIAKVAPA NTAVQVIAPP ERKISVWMGG SILASLSAFQ DMWITAAEFK EVGPNIVHQR CF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards