About Transmembrane protease serine 13
Transmembrane protease serine 13 (TMPRSS13) is a protein
from Homo sapiens identified by UniProt accession
Q9BYE2, 586 residues long.
MolForge cross-references it against 0 known binders and
56 disease associations.
Target properties
| Protein name | Transmembrane protease serine 13 |
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| UniProt accession | Q9BYE2 |
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| Gene | TMPRSS13 |
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| Organism | Homo sapiens |
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| Length | 586 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (56)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.30
- DNA methylation · score 0.24
- hereditary palmoplantar keratoderma, Gamborg-Nielsen type · score 0.05
- erythrokeratodermia variabilis · score 0.05
- Olmsted syndrome 1 · score 0.05
- pretibial dystrophic epidermolysis bullosa · score 0.04
- ichthyosis, lamellar, autosomal dominant · score 0.04
- Graham Little-Piccardi-Lassueur syndrome · score 0.04
- ichthyosis histrix, Lambert type · score 0.04
- hidradenitis suppurativa · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BYE2-F1 | alphafold | PREDICTED | 73.59 | — |
Amino-acid sequence (586 residues)
MERDSHGNAS PARTPSAGAS PAQASPAGTP PGRASPAQAS PAQASPAGTP PGRASPAQAS PAGTPPGRAS PGRASPAQAS PAQASPARAS PALASLSRSS SGRSSSARSA SVTTSPTRVY LVRATPVGAV PIRSSPARSA PATRATRESP GTSLPKFTWR EGQKQLPLIG CVLLLIALVV SLIILFQFWQ GHTGIRYKEQ RESCPKHAVR CDGVVDCKLK SDELGCVRFD WDKSLLKIYS GSSHQWLPIC SSNWNDSYSE KTCQQLGFES AHRTTEVAHR DFANSFSILR YNSTIQESLH RSECPSQRYI SLQCSHCGLR AMTGRIVGGA LASDSKWPWQ VSLHFGTTHI CGGTLIDAQW VLTAAHCFFV TREKVLEGWK VYAGTSNLHQ LPEAASIAEI IINSNYTDEE DDYDIALMRL SKPLTLSAHI HPACLPMHGQ TFSLNETCWI TGFGKTRETD DKTSPFLREV QVNLIDFKKC NDYLVYDSYL TPRMMCAGDL RGGRDSCQGD SGGPLVCEQN NRWYLAGVTS WGTGCGQRNK PGVYTKVTEV LPWIYSKMEV RSLQQDTAPS RLGTSSGGDP GGAPRL
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