Small proline-rich protein 2G (SPRR2G)

About Small proline-rich protein 2G

Small proline-rich protein 2G (SPRR2G) is a protein from Homo sapiens identified by UniProt accession Q9BYE4, 73 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.

Target properties

Protein name	Small proline-rich protein 2G
UniProt accession	Q9BYE4
Gene	SPRR2G
Organism	Homo sapiens
Length	73 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (19)

Diseases linked to this target (Open Targets).

esophageal cancer · score 0.17
low grade glioma · score 0.11
endometrial cancer · score 0.10
psoriasis · score 0.05
dysplasia · score 0.04
breast carcinoma · score 0.04
atopic eczema · score 0.02
oral squamous cell carcinoma · score 0.02
rosacea · score 0.02
acne · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BYE4-F1	alphafold	PREDICTED	78.22	—

Amino-acid sequence (73 residues)

MSYQQQQCKQ PCQPPPVCPT PKCPEPCPPP KCPEPYLPPP CPPEHCPPPP CQDKCPPVQP YPPCQQKYPP KSK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards