Polycomb group RING finger protein 6 (PCGF6)

About Polycomb group RING finger protein 6

Polycomb group RING finger protein 6 (PCGF6) is a protein from Homo sapiens identified by UniProt accession Q9BYE7, 350 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.

Target properties

Protein name	Polycomb group RING finger protein 6
UniProt accession	Q9BYE7
Gene	PCGF6
Organism	Homo sapiens
Length	350 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (30)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.36
cortical surface area measurement · score 0.10
body height · score 0.09
thalamus volume · score 0.06
mean corpuscular volume · score 0.06
brain volume measurement · score 0.04
glomerular filtration rate · score 0.04
autosomal dominant spondylocostal dysostosis · score 0.04
intracranial volume measurement · score 0.04
autosomal recessive spondylocostal dysostosis · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BYE7-F1	alphafold	PREDICTED	71.97	—

Amino-acid sequence (350 residues)

MEGVAVVTAG SVGAAKTEGA AALPPPPPVS PPALTPAPAA GEEGPAPLSE TGAPGCSGSR PPELEPERSL GRFRGRFEDE DEELEEEEEL EEEEEEEEED MSHFSLRLEG GRQDSEDEEE RLINLSELTP YILCSICKGY LIDATTITEC LHTFCKSCIV RHFYYSNRCP KCNIVVHQTQ PLYNIRLDRQ LQDIVYKLVI NLEEREKKQM HDFYKERGLE VPKPAVPQPV PSSKGRSKKV LESVFRIPPE LDMSLLLEFI GANEGTGHFK PLEKKFVRVS GEATIGHVEK FLRRKMGLDP ACQVDIICGD HLLEQYQTLR EIRRAIGDAA MQDGLLVLHY GLVVSPLKIT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards