Partitioning defective 6 homolog gamma (PARD6G)

About Partitioning defective 6 homolog gamma

Partitioning defective 6 homolog gamma (PARD6G) is a protein from Homo sapiens identified by UniProt accession Q9BYG4, 376 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.

Target properties

Protein name	Partitioning defective 6 homolog gamma
UniProt accession	Q9BYG4
Gene	PARD6G
Organism	Homo sapiens
Length	376 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (30)

Diseases linked to this target (Open Targets).

age-related hearing impairment · score 0.27
acne · score 0.25
myeloid white cell count · score 0.20
neutrophil count · score 0.16
head and neck squamous cell carcinoma · score 0.15
leukocyte count · score 0.13
Abnormal abdomen morphology · score 0.11
Abnormal delivery · score 0.11
gastric adenocarcinoma · score 0.09
appendicular lean mass · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BYG4-F1	alphafold	PREDICTED	70.03	—

Amino-acid sequence (376 residues)

MNRSFHKSQT LRFYDCSAVE VKSKFGAEFR RFSLDRHKPG KFEDFYKLVV HTHHISNSDV TIGYADVHGD LLPINNDDNF CKAVSSANPL LRVFIQKREE AERGSLGAGS LCRRRRALGA LRDEGPRRRA HLDIGLPRDF RPVSSIIDVD LVPETHRRVR LHRHGCEKPL GFYIRDGASV RVTPHGLEKV PGIFISRMVP GGLAESTGLL AVNDEVLEVN GIEVAGKTLD QVTDMMIANS HNLIVTVKPA NQRNNVVRGG RALGSSGPPS DGTAGFVGPP APRVLQNFHP DEAESDEDND VVIEGTLEPA RPPQTPGAPA GSLSRVNGAG LAQRLQRDLA LDGGLQRLLS SLRADPRHSL ALPPGGVEEH GPAVTL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards