Partitioning defective 6 homolog beta (PARD6B)

About Partitioning defective 6 homolog beta

Partitioning defective 6 homolog beta (PARD6B) is a protein from Homo sapiens identified by UniProt accession Q9BYG5, 372 residues long. MolForge cross-references it against 0 known binders and 70 disease associations.

Target properties

Protein name	Partitioning defective 6 homolog beta
UniProt accession	Q9BYG5
Gene	PARD6B
Organism	Homo sapiens
Length	372 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (70)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.35
colorectal cancer · score 0.33
serum gamma-glutamyl transferase measurement · score 0.32
breast adenocarcinoma · score 0.25
endometrial cancer · score 0.23
glioblastoma multiforme · score 0.16
gastric carcinoma · score 0.15
head and neck squamous cell carcinoma · score 0.15
monocyte percentage of leukocytes · score 0.14
gastric adenocarcinoma · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BYG5-F1	alphafold	PREDICTED	70.46	—

Amino-acid sequence (372 residues)

MNRSHRHGAG SGCLGTMEVK SKFGAEFRRF SLERSKPGKF EEFYGLLQHV HKIPNVDVLV GYADIHGDLL PINNDDNYHK AVSTANPLLR IFIQKKEEAD YSAFGTDTLI KKKNVLTNVL RPDNHRKKPH IVISMPQDFR PVSSIIDVDI LPETHRRVRL YKYGTEKPLG FYIRDGSSVR VTPHGLEKVP GIFISRLVPG GLAQSTGLLA VNDEVLEVNG IEVSGKSLDQ VTDMMIANSR NLIITVRPAN QRNNVVRNSR TSGSSGQSTD NSLLGYPQQI EPSFEPEDED SEEDDIIIED NGVPQQIPKA VPNTESLESL TQIELSFESG QNGFIPSNEV SLAAIASSSN TEFETHAPDQ KLLEEDGTII TL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards