About NF-kappa-B inhibitor zeta
NF-kappa-B inhibitor zeta (NFKBIZ) is a protein
from Homo sapiens identified by UniProt accession
Q9BYH8, 718 residues long.
MolForge cross-references it against 0 known binders and
429 disease associations.
Target properties
| Protein name | NF-kappa-B inhibitor zeta |
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| UniProt accession | Q9BYH8 |
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| Gene | NFKBIZ |
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| Organism | Homo sapiens |
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| Length | 718 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (429)
Diseases linked to this target (Open Targets).
- psoriasis · score 0.41
- psoriasis vulgaris · score 0.34
- type 2 diabetes mellitus · score 0.31
- serum non-albumin protein measurement · score 0.29
- peritonsillar abscess · score 0.28
- neurodegenerative disease · score 0.27
- PHF-tau measurement · score 0.27
- aspartate aminotransferase measurement · score 0.11
- C-reactive protein measurement · score 0.11
- breast cancer · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BYH8-F1 | alphafold | PREDICTED | 57.69 | — |
Amino-acid sequence (718 residues)
MIVDKLLDDS RGGEGLRDAA GGCGLMTSPL NLSYFYGASP PAAAPGACDA SCSVLGPSAP GSPGSDSSDF SSASSVSSCG AVESRSRGGA RAERQPVEPH MGVGRQQRGP FQGVRVKNSV KELLLHIRSH KQKASGQAVD DFKTQGVNIE QFRELKNTVS YSGKRKGPDS LSDGPACKRP ALLHSQFLTP PQTPTPGESM EDVHLNEPKQ ESSADLLQNI INIKNECSPV SLNTVQVSWL NPVVVPQSSP AEQCQDFHGG QVFSPPQKCQ PFQVRGSQQM IDQASLYQYS PQNQHVEQQP HYTHKPTLEY SPFPIPPQSP AYEPNLFDGP ESQFCPNQSL VSLLGDQRES ENIANPMQTS SSVQQQNDAH LHSFSMMPSS ACEAMVGHEM ASDSSNTSLP FSNMGNPMNT TQLGKSLFQW QVEQEESKLA NISQDQFLSK DADGDTFLHI AVAQGRRALS YVLARKMNAL HMLDIKEHNG QSAFQVAVAA NQHLIVQDLV NIGAQVNTTD CWGRTPLHVC AEKGHSQVLQ AIQKGAVGSN QFVDLEATNY DGLTPLHCAV IAHNAVVHEL QRNQQPHSPE VQELLLKNKS LVDTIKCLIQ MGAAVEAKDR KSGRTALHLA AEEANLELIR LFLELPSCLS FVNAKAYNGN TALHVAASLQ YRLTQLDAVR LLMRKGADPS TRNLENEQPV HLVPDGPVGE QIRRILKGKS IQQRAPPY
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