About Hydroperoxide isomerase ALOXE3
Hydroperoxide isomerase ALOXE3 (ALOXE3) is a protein
from Homo sapiens identified by UniProt accession
Q9BYJ1, 711 residues long.
MolForge cross-references it against 0 known binders and
148 disease associations.
Target properties
| Protein name | Hydroperoxide isomerase ALOXE3 |
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| UniProt accession | Q9BYJ1 |
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| Gene | ALOXE3 |
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| Organism | Homo sapiens |
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| Length | 711 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (148)
Diseases linked to this target (Open Targets).
- autosomal recessive congenital ichthyosis · score 0.66
- congenital non-bullous ichthyosiform erythroderma · score 0.62
- lamellar ichthyosis · score 0.59
- self-healing collodion baby · score 0.56
- ichthyosis · score 0.42
- Brachycephaly · score 0.34
- Tapered finger · score 0.34
- Intellectual disability · score 0.34
- scoliosis · score 0.34
- Severe failure to thrive · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BYJ1-F1 | alphafold | PREDICTED | 91.50 | — |
Amino-acid sequence (711 residues)
MAVYRLCVTT GPYLRAGTLD NISVTLVGTC GESPKQRLDR MGRDFAPGSV QKYKVRCTAE LGELLLLRVH KERYAFFRKD SWYCSRICVT EPDGSVSHFP CYQWIEGYCT VELRPGTART ICQDSLPLLL DHRTRELRAR QECYRWKIYA PGFPCMVDVN SFQEMESDKK FALTKTTTCV DQGDSSGNRY LPGFPMKIDI PSLMYMEPNV RYSATKTISL LFNAIPASLG MKLRGLLDRK GSWKKLDDMQ NIFWCHKTFT TKYVTEHWCE DHFFGYQYLN GVNPVMLHCI SSLPSKLPVT NDMVAPLLGQ DTCLQTELER GNIFLADYWI LAEAPTHCLN GRQQYVAAPL CLLWLSPQGA LVPLAIQLSQ TPGPDSPIFL PTDSEWDWLL AKTWVRNSEF LVHENNTHFL CTHLLCEAFA MATLRQLPLC HPIYKLLLPH TRYTLQVNTI ARATLLNPEG LVDQVTSIGR QGLIYLMSTG LAHFTYTNFC LPDSLRARGV LAIPNYHYRD DGLKIWAAIE SFVSEIVGYY YPSDASVQQD SELQAWTGEI FAQAFLGRES SGFPSRLCTP GEMVKFLTAI IFNCSAQHAA VNSGQHDFGA WMPNAPSSMR QPPPQTKGTT TLKTYLDTLP EVNISCNNLL LFWLVSQEPK DQRPLGTYPD EHFTEEAPRR SIAAFQSRLA QISRDIQERN QGLALPYTYL DPPLIENSVS I
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