E3 ubiquitin-protein ligase TRIM34 (TRIM34)

About E3 ubiquitin-protein ligase TRIM34

E3 ubiquitin-protein ligase TRIM34 (TRIM34) is a protein from Homo sapiens identified by UniProt accession Q9BYJ4, 488 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase TRIM34
UniProt accession	Q9BYJ4
Gene	TRIM34
Organism	Homo sapiens
Length	488 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (29)

Diseases linked to this target (Open Targets).

PHF-tau measurement · score 0.17
Familial prostate cancer · score 0.11
prostate cancer · score 0.11
prostate carcinoma · score 0.11
apolipoprotein B measurement · score 0.09
infection · score 0.07
infect · score 0.07
low density lipoprotein cholesterol measurement · score 0.03
non-small cell lung carcinoma · score 0.03
platelet count · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BYJ4-F1	alphafold	PREDICTED	86.42	—

Amino-acid sequence (488 residues)

MASKILLNVQ EEVTCPICLE LLTEPLSLDC GHSLCRACIT VSNKEAVTSM GGKSSCPVCG ISYSFEHLQA NQHLANIVER LKEVKLSPDN GKKRDLCDHH GEKLLLFCKE DRKVICWLCE RSQEHRGHHT VLTEEVFKEC QEKLQAVLKR LKKEEEEAEK LEADIREEKT SWKYQVQTER QRIQTEFDQL RSILNNEEQR ELQRLEEEEK KTLDKFAEAE DELVQQKQLV RELISDVECR SQWSTMELLQ DMSGIMKWSE IWRLKKPKMV SKKLKTVFHA PDLSRMLQMF RELTAVRCYW VDVTLNSVNL NLNLVLSEDQ RQVISVPIWP FQCYNYGVLG SQYFSSGKHY WEVDVSKKTA WILGVYCRTY SRHMKYVVRR CANRQNLYTK YRPLFGYWVI GLQNKCKYGV FEESLSSDPE VLTLSMAVPP CRVGVFLDYE AGIVSFFNVT SHGSLIYKFS KCCFSQPVYP YFNPWNCPAP MTLCPPSS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards