About YTH domain-containing family protein 1
YTH domain-containing family protein 1 (YTHDF1) is a protein
from Homo sapiens identified by UniProt accession
Q9BYJ9, 559 residues long.
MolForge cross-references it against 0 known binders and
215 disease associations.
Target properties
| Protein name | YTH domain-containing family protein 1 |
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| UniProt accession | Q9BYJ9 |
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| Gene | YTHDF1 |
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| Organism | Homo sapiens |
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| Length | 559 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (215)
Diseases linked to this target (Open Targets).
- neuroticism measurement · score 0.16
- neoplasm · score 0.12
- hepatocellular carcinoma · score 0.12
- gonorrhea · score 0.11
- cancer · score 0.10
- non-small cell lung carcinoma · score 0.10
- colorectal carcinoma · score 0.08
- head and neck squamous cell carcinoma · score 0.08
- glioblastoma multiforme · score 0.08
- esophageal squamous cell carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BYJ9-F1 | alphafold | PREDICTED | 61.52 | — |
Amino-acid sequence (559 residues)
MSATSVDTQR TKGQDNKVQN GSLHQKDTVH DNDFEPYLTG QSNQSNSYPS MSDPYLSSYY PPSIGFPYSL NEAPWSTAGD PPIPYLTTYG QLSNGDHHFM HDAVFGQPGG LGNNIYQHRF NFFPENPAFS AWGTSGSQGQ QTQSSAYGSS YTYPPSSLGG TVVDGQPGFH SDTLSKAPGM NSLEQGMVGL KIGDVSSSAV KTVGSVVSSV ALTGVLSGNG GTNVNMPVSK PTSWAAIASK PAKPQPKMKT KSGPVMGGGL PPPPIKHNMD IGTWDNKGPV PKAPVPQQAP SPQAAPQPQQ VAQPLPAQPP ALAQPQYQSP QQPPQTRWVA PRNRNAAFGQ SGGAGSDSNS PGNVQPNSAP SVESHPVLEK LKAAHSYNPK EFEWNLKSGR VFIIKSYSED DIHRSIKYSI WCSTEHGNKR LDSAFRCMSS KGPVYLLFSV NGSGHFCGVA EMKSPVDYGT SAGVWSQDKW KGKFDVQWIF VKDVPNNQLR HIRLENNDNK PVTNSRDTQE VPLEKAKQVL KIISSYKHTT SIFDDFAHYE KRQEEEEVVR KERQSRNKQ
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