About RanBP-type and C3HC4-type zinc finger-containing protein 1
RanBP-type and C3HC4-type zinc finger-containing protein 1 (RBCK1) is a protein
from Homo sapiens identified by UniProt accession
Q9BYM8, 510 residues long.
MolForge cross-references it against 0 known binders and
99 disease associations.
Target properties
| Protein name | RanBP-type and C3HC4-type zinc finger-containing protein 1 |
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| UniProt accession | Q9BYM8 |
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| Gene | RBCK1 |
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| Organism | Homo sapiens |
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| Length | 510 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (99)
Diseases linked to this target (Open Targets).
- polyglucosan body myopathy 1 with or without immunodeficiency · score 0.79
- polyglucosan body myopathy · score 0.57
- genetic disorder · score 0.45
- autoinflammatory syndrome with pyogenic bacterial infection and amylopectinosis · score 0.37
- neuroinflammatory disorder · score 0.37
- neurodegenerative disease · score 0.37
- glycogen storage disease due to glycogen branching enzyme deficiency · score 0.34
- eosinophil count · score 0.25
- clear cell renal carcinoma · score 0.19
- eosinophil percentage of leukocytes · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BYM8-F1 | alphafold | PREDICTED | 84.03 | — |
Amino-acid sequence (510 residues)
MDEKTKKAEE MALSLTRAVA GGDEQVAMKC AIWLAEQRVP LSVQLKPEVS PTQDIRLWVS VEDAQMHTVT IWLTVRPDMT VASLKDMVFL DYGFPPVLQQ WVIGQRLARD QETLHSHGVR QNGDSAYLYL LSARNTSLNP QELQRERQLR MLEDLGFKDL TLQPRGPLEP GPPKPGVPQE PGRGQPDAVP EPPPVGWQCP GCTFINKPTR PGCEMCCRAR PEAYQVPASY QPDEEERARL AGEEEALRQY QQRKQQQQEG NYLQHVQLDQ RSLVLNTEPA ECPVCYSVLA PGEAVVLREC LHTFCRECLQ GTIRNSQEAE VSCPFIDNTY SCSGKLLERE IKALLTPEDY QRFLDLGISI AENRSAFSYH CKTPDCKGWC FFEDDVNEFT CPVCFHVNCL LCKAIHEQMN CKEYQEDLAL RAQNDVAARQ TTEMLKVMLQ QGEAMRCPQC QIVVQKKDGC DWIRCTVCHT EICWVTKGPR WGPGGPGDTS GGCRCRVNGI PCHPSCQNCH
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