Keratin-associated protein 4-5 (KRTAP4-5)

About Keratin-associated protein 4-5

Keratin-associated protein 4-5 (KRTAP4-5) is a protein from Homo sapiens identified by UniProt accession Q9BYR2, 181 residues long. MolForge cross-references it against 0 known binders and 12 disease associations.

Target properties

Protein name	Keratin-associated protein 4-5
UniProt accession	Q9BYR2
Gene	KRTAP4-5
Organism	Homo sapiens
Length	181 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (12)

Diseases linked to this target (Open Targets).

head and neck squamous cell carcinoma · score 0.18
prostate adenocarcinoma · score 0.18
glioblastoma multiforme · score 0.18
breast adenocarcinoma · score 0.18
esophageal cancer · score 0.14
neuroblastoma · score 0.13
low grade glioma · score 0.11
diabetes mellitus · score 0.00
neoplasm · score 0.00
hypopharyngeal carcinoma · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BYR2-F1	alphafold	PREDICTED	35.63	—

Amino-acid sequence (181 residues)

MVSSCCGSVS SEQSCGLENC CRPSCCQTTC CRTTCCRPSC CKPQCCQSVC YQPTCCHPSC CISSCCRPYC CESSCCRPCC CQTTCCRTTC CRTTCCCPSC CVSSCCRPQC CQSVCCQPTC CRPSCCISSC CHPSCCESSC CRPCCCVRPV CGRVSCHTTC YRPTCVISTC PRPLCCASSC C

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards