Keratin-associated protein 4-4 (KRTAP4-4)

About Keratin-associated protein 4-4

Keratin-associated protein 4-4 (KRTAP4-4) is a protein from Homo sapiens identified by UniProt accession Q9BYR3, 166 residues long. MolForge cross-references it against 0 known binders and 9 disease associations.

Target properties

Protein name	Keratin-associated protein 4-4
UniProt accession	Q9BYR3
Gene	KRTAP4-4
Organism	Homo sapiens
Length	166 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (9)

Diseases linked to this target (Open Targets).

head and neck squamous cell carcinoma · score 0.18
clear cell renal carcinoma · score 0.18
glioblastoma multiforme · score 0.18
thyroid gland adenocarcinoma · score 0.16
esophageal cancer · score 0.14
neuroblastoma · score 0.13
low grade glioma · score 0.11
diabetes mellitus · score 0.00
atopic eczema · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BYR3-F1	alphafold	PREDICTED	38.03	—

Amino-acid sequence (166 residues)

MVNSCCGSVC SDQGCGLENC CRPSYCQTTC CRTTCCRPSC CVSSCCRPQC CQTTCCRTTC CHPSCCVSSC CRPQCCQSVC CQPTCCRPQC CQTTCCRTTC CRPSCCRPQC CQSVCCQPTC CCPSYCVSSC CRPQCCQTTC CRTTCCRPSC CVSRCYRPHC GQSLCC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards