Leucine-rich repeat-containing protein 2 (LRRC2)

About Leucine-rich repeat-containing protein 2

Leucine-rich repeat-containing protein 2 (LRRC2) is a protein from Homo sapiens identified by UniProt accession Q9BYS8, 371 residues long. MolForge cross-references it against 0 known binders and 51 disease associations.

Target properties

Protein name	Leucine-rich repeat-containing protein 2
UniProt accession	Q9BYS8
Gene	LRRC2
Organism	Homo sapiens
Length	371 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (51)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.29
teratocarcinoma-derived growth factor 1 measurement · score 0.25
protein measurement · score 0.24
macrophage inflammatory protein 1b measurement · score 0.23
cerebrospinal fluid biomarker measurement · score 0.19
age at diagnosis · score 0.18
coronary atherosclerosis · score 0.18
Mumps virus infectious disease · score 0.17
CCL4 measurement · score 0.15
body height · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BYS8-F1	alphafold	PREDICTED	77.59	—

Amino-acid sequence (371 residues)

MGHKVVVFDI SVIRALWETR VKKHKAWQKK EVERLEKSAL EKIKEEWNFV AECRRKGIPQ AVYCKNGFID TSVRLLDKIE RNTLTRQSSL PKDRGKRSSA FVFELSGEHW TELPDSLKEQ THLREWYISN TLIQIIPTYI QLFQAMRILD LPKNQISHLP AEIGCLKNLK ELNVGFNYLK SIPPELGDCE NLERLDCSGN LELMELPFEL SNLKQVTFVD ISANKFSSVP ICVLRMSNLQ WLDISSNNLT DLPQDIDRLE ELQSFLLYKN KLTYLPYSML NLKKLTLLVV SGDHLVELPT ALCDSSTPLK FVSLMDNPID NAQCEDGNEI MESERDRQHF DKEVMKAYIE DLKERESVPS YTTKVSFSLQ L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards