About Alanine--glyoxylate aminotransferase 2, mitochondrial
Alanine--glyoxylate aminotransferase 2, mitochondrial (AGXT2) is a protein
from Homo sapiens identified by UniProt accession
Q9BYV1, 514 residues long.
MolForge cross-references it against 0 known binders and
83 disease associations.
Target properties
| Protein name | Alanine--glyoxylate aminotransferase 2, mitochondrial |
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| UniProt accession | Q9BYV1 |
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| Gene | AGXT2 |
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| Organism | Homo sapiens |
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| Length | 514 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (83)
Diseases linked to this target (Open Targets).
- urinary metabolite measurement · score 0.52
- serum metabolite measurement · score 0.50
- neurodegenerative disease · score 0.44
- serum dimethylarginine measurement · score 0.41
- 3-aminoisobutyrate measurement · score 0.37
- 3-hydroxyisobutyrate measurement · score 0.37
- metabolite measurement · score 0.32
- protein measurement · score 0.30
- beta-aminoisobutyric acid measurement · score 0.30
- symmetrical dimethylarginine measurement · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BYV1-F1 | alphafold | PREDICTED | 91.07 | — |
Amino-acid sequence (514 residues)
MTLIWRHLLR PLCLVTSAPR ILEMHPFLSL GTSRTSVTKL SLHTKPRMPP CDFMPERYQS LGYNRVLEIH KEHLSPVVTA YFQKPLLLHQ GHMEWLFDAE GSRYLDFFSG IVTVSVGHCH PKVNAVAQKQ LGRLWHTSTV FFHPPMHEYA EKLAALLPEP LKVIFLVNSG SEANELAMLM ARAHSNNIDI ISFRGAYHGC SPYTLGLTNV GTYKMELPGG TGCQPTMCPD VFRGPWGGSH CRDSPVQTIR KCSCAPDCCQ AKDQYIEQFK DTLSTSVAKS IAGFFAEPIQ GVNGVVQYPK GFLKEAFELV RARGGVCIAD EVQTGFGRLG SHFWGFQTHD VLPDIVTMAK GIGNGFPMAA VITTPEIAKS LAKCLQHFNT FGGNPMACAI GSAVLEVIKE ENLQENSQEV GTYMLLKFAK LRDEFEIVGD VRGKGLMIGI EMVQDKISCR PLPREEVNQI HEDCKHMGLL VGRGSIFSQT FRIAPSMCIT KPEVDFAVEV FRSALTQHME RRAK
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