Tripartite motif-containing protein 54 (TRIM54)

About Tripartite motif-containing protein 54

Tripartite motif-containing protein 54 (TRIM54) is a protein from Homo sapiens identified by UniProt accession Q9BYV2, 358 residues long. MolForge cross-references it against 0 known binders and 157 disease associations.

Target properties

Protein name	Tripartite motif-containing protein 54
UniProt accession	Q9BYV2
Gene	TRIM54
Organism	Homo sapiens
Length	358 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (157)

Diseases linked to this target (Open Targets).

mean corpuscular hemoglobin concentration · score 0.09
hepatocellular carcinoma · score 0.08
hypertrophic cardiomyopathy · score 0.07
Barrett's esophagus · score 0.06
dilated cardiomyopathy · score 0.06
left ventricular noncompaction · score 0.06
neoplasm · score 0.05
dilated cardiomyopathy 1M · score 0.05
autosomal recessive limb-girdle muscular dystrophy type 2E · score 0.05
Distal myotilinopathy · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BYV2-F1	alphafold	PREDICTED	83.13	—

Amino-acid sequence (358 residues)

MNFTVGFKPL LGDAHSMDNL EKQLICPICL EMFSKPVVIL PCQHNLCRKC ANDVFQASNP LWQSRGSTTV SSGGRFRCPS CRHEVVLDRH GVYGLQRNLL VENIIDIYKQ ESSRPLHSKA EQHLMCEEHE EEKINIYCLS CEVPTCSLCK VFGAHKDCEV APLPTIYKRQ KSELSDGIAM LVAGNDRVQA VITQMEEVCQ TIEDNSRRQK QLLNQRFESL CAVLEERKGE LLQALAREQE EKLQRVRGLI RQYGDHLEAS SKLVESAIQS MEEPQMALYL QQAKELINKV GAMSKVELAG RPEPGYESME QFTVRVEHVA EMLRTIDFQP GASGEEEEVA PDGEEGSAGP EEERPDGP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards