About Carotenoid-cleaving dioxygenase, mitochondrial
Carotenoid-cleaving dioxygenase, mitochondrial (BCO2) is a protein
from Homo sapiens identified by UniProt accession
Q9BYV7, 579 residues long.
MolForge cross-references it against 0 known binders and
68 disease associations.
Target properties
| Protein name | Carotenoid-cleaving dioxygenase, mitochondrial |
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| UniProt accession | Q9BYV7 |
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| Gene | BCO2 |
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| Organism | Homo sapiens |
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| Length | 579 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (68)
Diseases linked to this target (Open Targets).
- interleukin 18 measurement · score 0.29
- blood protein measurement · score 0.29
- response to vaccine · score 0.28
- cytokine measurement · score 0.28
- lung adenocarcinoma · score 0.22
- protein measurement · score 0.20
- interleukin-1 beta measurement · score 0.20
- cutaneous melanoma · score 0.18
- breast adenocarcinoma · score 0.15
- head and neck squamous cell carcinoma · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BYV7-F1 | alphafold | PREDICTED | 88.46 | — |
Amino-acid sequence (579 residues)
MFFRVFLHFI RSHSATAVDF LPVMVHRLPV FKRYMGNTPQ KKAVFGQCRG LPCVAPLLTT VEEAPRGISA RVWGHFPKWL NGSLLRIGPG KFEFGKDKYN HWFDGMALLH QFRMAKGTVT YRSKFLQSDT YKANSAKNRI VISEFGTLAL PDPCKNVFER FMSRFELPGK AAAMTDNTNV NYVRYKGDYY LCTETNFMNK VDIETLEKTE KVDWSKFIAV NGATAHPHYD LDGTAYNMGN SFGPYGFSYK VIRVPPEKVD LGETIHGVQV ICSIASTEKG KPSYYHSFGM TRNYIIFIEQ PLKMNLWKIA TSKIRGKAFS DGISWEPQCN TRFHVVEKRT GQLLPGRYYS KPFVTFHQIN AFEDQGCVII DLCCQDNGRT LEVYQLQNLR KAGEGLDQVH NSAAKSFPRR FVLPLNVSLN APEGDNLSPL SYTSASAVKQ ADGTIWCSHE NLHQEDLEKE GGIEFPQIYY DRFSGKKYHF FYGCGFRHLV GDSLIKVDVV NKTLKVWRED GFYPSEPVFV PAPGTNEEDG GVILSVVITP NQNESNFILV LDAKNFEELG RAEVPVQMPY GFHGTFIPI
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