Centrosomal protein of 41 kDa (CEP41)

About Centrosomal protein of 41 kDa

Centrosomal protein of 41 kDa (CEP41) is a protein from Homo sapiens identified by UniProt accession Q9BYV8, 373 residues long. MolForge cross-references it against 0 known binders and 66 disease associations.

Target properties

Protein name	Centrosomal protein of 41 kDa
UniProt accession	Q9BYV8
Gene	CEP41
Organism	Homo sapiens
Length	373 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (66)

Diseases linked to this target (Open Targets).

Joubert syndrome · score 0.79
genetic disorder · score 0.45
Joubert syndrome with ocular defect · score 0.37
low grade glioma · score 0.23
breast adenocarcinoma · score 0.23
azoospermia · score 0.05
male infertility with teratozoospermia due to single gene mutation · score 0.04
spermatogenic failure 65 · score 0.03
aneurysm, intracranial berry, 12 · score 0.03
spermatogenic failure 72 · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BYV8-F1	alphafold	PREDICTED	69.89	—

Amino-acid sequence (373 residues)

MSLRRHIGNP EYLMKRIPQN PRYQHIKSRL DTGNSMTKYT EKLEEIKKNY RYKKDELFKR LKVTTFAQLI IQVASLSDQT LEVTAEEIQR LEDNDSAASD PDAETTARTN GKGNPGEQSP SPEQFINNAG AGDSSRSTLQ SVISGVGELD LDKGPVKKAE PHTKDKPYPD CPFLLLDVRD RDSYQQCHIV GAYSYPIATL SRTMNPYSND ILEYKNAHGK IIILYDDDER LASQAATTMC ERGFENLFML SGGLKVLAQK FPEGLITGSL PASCQQALPP GSARKRSSPK GPPLPAENKW RFTPEDLKKI EYYLEEEQGP ADHPSRLNQA NSSGRESKVP GARSAQNLPG GGPASHSNPR SLSSGHLQGK PWK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards