About TBC1 domain family member 2A
TBC1 domain family member 2A (TBC1D2) is a protein
from Homo sapiens identified by UniProt accession
Q9BYX2, 928 residues long.
MolForge cross-references it against 0 known binders and
29 disease associations.
Target properties
| Protein name | TBC1 domain family member 2A |
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| UniProt accession | Q9BYX2 |
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| Gene | TBC1D2 |
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| Organism | Homo sapiens |
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| Length | 928 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (29)
Diseases linked to this target (Open Targets).
- smoking status measurement · score 0.24
- urate measurement · score 0.21
- bone density · score 0.21
- drug use measurement · score 0.20
- adolescent idiopathic scoliosis · score 0.10
- homocysteine measurement · score 0.05
- neoplasm · score 0.03
- alcohol consumption measurement · score 0.03
- childhood trauma measurement · score 0.03
- esophageal squamous cell carcinoma · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BYX2-F1 | alphafold | PREDICTED | 74.76 | — |
Amino-acid sequence (928 residues)
MEGAGENAPE SSSSAPGSEE SARDPQVPPP EEESGDCARS LEAVPKKLCG YLSKFGGKGP IRGWKSRWFF YDERKCQLYY SRTAQDANPL DSIDLSSAVF DCKADAEEGI FEIKTPSRVI TLKAATKQAM LYWLQQLQMK RWEFHNSPPA PPATPDAALA GNGPVLHLEL GQEEAELEEF LCPVKTPPGL VGVAAALQPF PALQNISLKH LGTEIQNTMH NIRGNKQAQG TGHEPPGEDS PQSGEPQREE QPLASDASTP GREPEDSPKP APKPSLTISF AQKAKRQNNT FPFFSEGITR NRTAQEKVAA LEQQVLMLTK ELKSQKELVK ILHKALEAAQ QEKRASSAYL AAAEDKDRLE LVRHKVRQIA ELGRRVEALE QERESLAHTA SLREQQVQEL QQHVQLLMDK NHAKQQVICK LSEKVTQDFT HPPDQSPLRP DAANRDFLSQ QGKIEHLKDD MEAYRTQNCF LNSEIHQVTK IWRKVAEKEK ALLTKCAYLQ ARNCQVESKY LAGLRRLQEA LGDEASECSE LLRQLVQEAL QWEAGEASSD SIELSPISKY DEYGFLTVPD YEVEDLKLLA KIQALESRSH HLLGLEAVDR PLRERWAALG DLVPSAELKQ LLRAGVPREH RPRVWRWLVH LRVQHLHTPG CYQELLSRGQ AREHPAARQI ELDLNRTFPN NKHFTCPTSS FPDKLRRVLL AFSWQNPTIG YCQGLNRLAA IALLVLEEEE SAFWCLVAIV ETIMPADYYC NTLTASQVDQ RVLQDLLSEK LPRLMAHLGQ HHVDLSLVTF NWFLVVFADS LISNILLRVW DAFLYEGTKV VFRYALAIFK YNEKEILRLQ NGLEIYQYLR FFTKTISNSR KLMNIAFNDM NPFRMKQLRQ LRMVHRERLE AELRELEQLK AEYLERRASR RRAVSEGCAS EDEVEGEA
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