About Pantothenate kinase 2, mitochondrial
Pantothenate kinase 2, mitochondrial (PANK2) is a protein
from Homo sapiens identified by UniProt accession
Q9BZ23, 570 residues long.
MolForge cross-references it against 0 known binders and
184 disease associations.
Target properties
| Protein name | Pantothenate kinase 2, mitochondrial |
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| UniProt accession | Q9BZ23 |
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| Gene | PANK2 |
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| Organism | Homo sapiens |
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| Length | 570 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (184)
Diseases linked to this target (Open Targets).
- pantothenate kinase-associated neurodegeneration · score 0.83
- Dystonia · score 0.63
- classic pantothenate kinase-associated neurodegeneration · score 0.62
- genetic disorder · score 0.50
- neurodegeneration with brain iron accumulation · score 0.47
- retinitis pigmentosa · score 0.44
- Neurodegeneration · score 0.43
- dystonic disorder · score 0.40
- atypical pantothenate kinase-associated neurodegeneration · score 0.37
- Cone rod dystrophy · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BZ23-F1 | alphafold | PREDICTED | 73.61 | — |
Amino-acid sequence (570 residues)
MRRLGPFHPR VHWAAPPSLS SGLHRLLFLR GTRIPSSTTL SPPRHDSLSL DGGTVNPPRV REPTGREAFG PSPASSDWLP ARWRNGRGGR PRARLCSGWT AAEEARRNPT LGGLLGRQRL LLRMGGGRLG APMERHGRAS ATSVSSAGEQ AAGDPEGRRQ EPLRRRASSA SVPAVGASAE GTRRDRLGSY SGPTSVSRQR VESLRKKRPL FPWFGLDIGG TLVKLVYFEP KDITAEEEEE EVESLKSIRK YLTSNVAYGS TGIRDVHLEL KDLTLCGRKG NLHFIRFPTH DMPAFIQMGR DKNFSSLHTV FCATGGGAYK FEQDFLTIGD LQLCKLDELD CLIKGILYID SVGFNGRSQC YYFENPADSE KCQKLPFDLK NPYPLLLVNI GSGVSILAVY SKDNYKRVTG TSLGGGTFFG LCCLLTGCTT FEEALEMASR GDSTKVDKLV RDIYGGDYER FGLPGWAVAS SFGNMMSKEK REAVSKEDLA RATLITITNN IGSIARMCAL NENINQVVFV GNFLRINTIA MRLLAYALDY WSKGQLKALF SEHEGYFGAV GALLELLKIP
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