About Dedicator of cytokinesis protein 9
Dedicator of cytokinesis protein 9 (DOCK9) is a protein
from Homo sapiens identified by UniProt accession
Q9BZ29, 2069 residues long.
MolForge cross-references it against 0 known binders and
96 disease associations.
Target properties
| Protein name | Dedicator of cytokinesis protein 9 |
|---|
| UniProt accession | Q9BZ29 |
|---|
| Gene | DOCK9 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 2069 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (96)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.44
- bone quantitative ultrasound measurement · score 0.43
- lean body mass · score 0.42
- FEV/FVC ratio · score 0.40
- appendicular lean mass · score 0.37
- leukocyte count · score 0.35
- bone density · score 0.35
- fat body mass · score 0.33
- body height · score 0.33
- cortical surface area measurement · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BZ29-F1 | alphafold | PREDICTED | 78.84 | — |
Amino-acid sequence (2069 residues)
MSQPPLLPAS AETRKFTRAL SKPGTAAELR QSVSEVVRGS VLLAKPKLIE PLDYENVIVQ KKTQILNDCL REMLLFPYDD FQTAILRRQG RYICSTVPAK AEEEAQSLFV TECIKTYNSD WHLVNYKYED YSGEFRQLPN KVVKLDKLPV HVYEVDEEVD KDEDAASLGS QKGGITKHGW LYKGNMNSAI SVTMRSFKRR FFHLIQLGDG SYNLNFYKDE KISKEPKGSI FLDSCMGVVQ NNKVRRFAFE LKMQDKSSYL LAADSEVEME EWITILNKIL QLNFEAAMQE KRNGDSHEDD EQSKLEGSGS GLDSYLPELA KSAREAEIKL KSESRVKLFY LDPDAQKLDF SSAEPEVKSF EEKFGKRILV KCNDLSFNLQ CCVAENEEGP TTNVEPFFVT LSLFDIKYNR KISADFHVDL NHFSVRQMLA TTSPALMNGS GQSPSVLKGI LHEAAMQYPK QGIFSVTCPH PDIFLVARIE KVLQGSITHC AEPYMKSSDS SKVAQKVLKN AKQACQRLGQ YRMPFAWAAR TLFKDASGNL DKNARFSAIY RQDSNKLSND DMLKLLADFR KPEKMAKLPV ILGNLDITID NVSSDFPNYV NSSYIPTKQF ETCSKTPITF EVEEFVPCIP KHTQPYTIYT NHLYVYPKYL KYDSQKSFAK ARNIAICIEF KDSDEEDSQP LKCIYGRPGG PVFTRSAFAA VLHHHQNPEF YDEIKIELPT QLHEKHHLLL TFFHVSCDNS SKGSTKKRDV VETQVGYSWL PLLKDGRVVT SEQHIPVSAN LPSGYLGYQE LGMGRHYGPE IKWVDGGKPL LKISTHLVST VYTQDQHLHN FFQYCQKTES GAQALGNELV KYLKSLHAME GHVMIAFLPT ILNQLFRVLT RATQEEVAVN VTRVIIHVVA QCHEEGLESH LRSYVKYAYK AEPYVASEYK TVHEELTKSM TTILKPSADF LTSNKLLKYS WFFFDVLIKS MAQHLIENSK VKLLRNQRFP ASYHHAVETV VNMLMPHITQ KFRDNPEASK NANHSLAVFI KRCFTFMDRG FVFKQINNYI SCFAPGDPKT LFEYKFEFLR VVCNHEHYIP LNLPMPFGKG RIQRYQDLQL DYSLTDEFCR NHFLVGLLLR EVGTALQEFR EVRLIAISVL KNLLIKHSFD DRYASRSHQA RIATLYLPLF GLLIENVQRI NVRDVSPFPV NAGMTVKDES LALPAVNPLV TPQKGSTLDN SLHKDLLGAI SGIASPYTTS TPNINSVRNA DSRGSLISTD SGNSLPERNS EKSNSLDKHQ QSSTLGNSVV RCDKLDQSEI KSLLMCFLYI LKSMSDDALF TYWNKASTSE LMDFFTISEV CLHQFQYMGK RYIARTGMMH ARLQQLGSLD NSLTFNHSYG HSDADVLHQS LLEANIATEV CLTALDTLSL FTLAFKNQLL ADHGHNPLMK KVFDVYLCFL QKHQSETALK NVFTALRSLI YKFPSTFYEG RADMCAALCY EILKCCNSKL SSIRTEASQL LYFLMRNNFD YTGKKSFVRT HLQVIISVSQ LIADVVGIGG TRFQQSLSII NNCANSDRLI KHTSFSSDVK DLTKRIRTVL MATAQMKEHE NDPEMLVDLQ YSLAKSYAST PELRKTWLDS MARIHVKNGD LSEAAMCYVH VTALVAEYLT RKEAVQWEPP LLPHSHSACL RRSRGGVFRQ GCTAFRVITP NIDEEASMME DVGMQDVHFN EDVLMELLEQ CADGLWKAER YELIADIYKL IIPIYEKRRD FERLAHLYDT LHRAYSKVTE VMHSGRRLLG TYFRVAFFGQ AAQYQFTDSE TDVEGFFEDE DGKEYIYKEP KLTPLSEISQ RLLKLYSDKF GSENVKMIQD SGKVNPKDLD SKYAYIQVTH VIPFFDEKEL QERKTEFERS HNIRRFMFEM PFTQTGKRQG GVEEQCKRRT ILTAIHCFPY VKKRIPVMYQ HHTDLNPIEV AIDEMSKKVA ELRQLCSSAE VDMIKLQLKL QGSVSVQVNA GPLAYARAFL DDTNTKRYPD NKVKLLKEVF RQFVEACGQA LAVNERLIKE DQLEYQEEMK ANYREMAKEL SEIMHEQLG
Explore Dedicator of cytokinesis protein 9 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets