About Membrane-associated phosphatidylinositol transfer protein 3
Membrane-associated phosphatidylinositol transfer protein 3 (PITPNM3) is a protein
from Homo sapiens identified by UniProt accession
Q9BZ71, 974 residues long.
MolForge cross-references it against 0 known binders and
70 disease associations.
Target properties
| Protein name | Membrane-associated phosphatidylinositol transfer protein 3 |
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| UniProt accession | Q9BZ71 |
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| Gene | PITPNM3 |
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| Organism | Homo sapiens |
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| Length | 974 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (70)
Diseases linked to this target (Open Targets).
- Cone rod dystrophy · score 0.48
- cone dystrophy · score 0.34
- Cerebral arteriovenous malformation · score 0.34
- glioblastoma multiforme · score 0.19
- breast adenocarcinoma · score 0.18
- Retinal dystrophy · score 0.17
- pulse pressure measurement · score 0.17
- attention deficit hyperactivity disorder · score 0.16
- antisocial behaviour measurement · score 0.16
- substance abuse · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BZ71-F1 | alphafold | PREDICTED | 66.16 | — |
Amino-acid sequence (974 residues)
MAKAGRAGGP PPGGGAPWHL RNVLSDSVES SDDEFFDARE EMAEGKNAIL IGMSQWNSND LVEQIETMGK LDEHQGEGTA PCTSSILQEK QRELYRVSLR RQRFPAQGSI EIHEDSEEGC PQRSCKTHVL LLVLHGGNIL DTGAGDPSCK AADIHTFSSV LEKVTRAHFP AALGHILIKF VPCPAICSEA FSLVSHLNPY SHDEGCLSSS QDHVPLAALP LLAISSPQYQ DAVATVIERA NQVYREFLKS SDGIGFSGQV CLIGDCVGGL LAFDAICYSA GPSGDSPASS SRKGSISSTQ DTPVAVEEDC SLASSKRLSK SNIDISSGLE DEEPKRPLPR KQSDSSTYDC EAITQHHAFL SSIHSSVLKD ESETPAAGGP QLPEVSLGRF DFDVSDFFLF GSPLGLVLAM RRTVLPGLDG FQVRPACSQV YSFFHCADPS ASRLEPLLEP KFHLVPPVSV PRYQRFPLGD GQSLLLADAL HTHSPLFLEG SSRDSPPLLD APASPPQASR FQRPGRRMSE GSSHSESSES SDSMAPVGAS RITAKWWGSK RIDYALYCPD VLTAFPTVAL PHLFHASYWE STDVVAFILR QVMRYESVNI KESARLDPAA LSPANPREKW LRKRTQVKLR NVTANHRAND VIAAEDGPQV LVGRFMYGPL DMVALTGEKV DILVMAEPSS GRWVHLDTEI TNSSGRITYN VPRPRRLGVG VYPVKMVVRG DQTCAMSYLT VLPRGMECVV FSIDGSFAAS VSIMGSDPKV RPGAVDVVRH WQDLGYMILY ITGRPDMQKQ RVVSWLSQHN FPQGMIFFSD GLVHDPLRQK AIFLRNLMQE CFIKISAAYG STKDISVYSV LGLPASQIFI VGRPTKKYQT QCQFLSEGYA AHLAALEASH RSRPKKNNSR MILRKGSFGL HAQPEFLRKR NHLRRTMSVQ QPDPPAANPK PERAQSQPES DKDHERPLPA LSWARGPPKF ESVP
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