About Contactin-associated protein-like 3
Contactin-associated protein-like 3 (CNTNAP3) is a protein
from Homo sapiens identified by UniProt accession
Q9BZ76, 1288 residues long.
MolForge cross-references it against 0 known binders and
27 disease associations.
Target properties
| Protein name | Contactin-associated protein-like 3 |
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| UniProt accession | Q9BZ76 |
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| Gene | CNTNAP3 |
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| Organism | Homo sapiens |
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| Length | 1288 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (27)
Diseases linked to this target (Open Targets).
- specific language impairment · score 0.09
- 7q11.23 microduplication syndrome · score 0.07
- Monoamine oxidase A deficiency · score 0.07
- microangiopathy and leukoencephalopathy, pontine, autosomal dominant · score 0.05
- myxosarcoma · score 0.03
- esophageal squamous cell carcinoma · score 0.02
- schizophrenia · score 0.01
- bladder exstrophy · score 0.01
- cutaneous lupus erythematosus · score 0.01
- gastric carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BZ76-F1 | alphafold | PREDICTED | 82.86 | — |
Amino-acid sequence (1288 residues)
MASVAWAVLK VLLLLPTQTW SPVGAGNPPD CDAPLASALP RSSFSSSSEL SSSHGPGFSR LNRRDGAGGW TPLVSNKYQW LQIDLGERME VTAVATQGGY GSSDWVTSYL LMFSDGGRNW KQYRREESIW GFPGNTNADS VVHYRLQPPF EARFLRFLPL AWNPRGRIGM RIEVYGCAYK SEVVYFDGQS ALLYRLDKKP LKPIRDVISL KFKAMQSNGI LLHREGQHGN HITLELIKGK LVFFLNSGNA KLPSTIAPVT LTLGSLLDDQ HWHSVLIELL DTQVNFTVDK HTHHFQAKGD SSYLDLNFEI SFGGIPTPGR SRAFRRKSFH GCLENLYYNG VDVTELAKKH KPQILMMGNV SFSCPQPQTV PVTFLSSRSY LALPGNSGED KVSVTFQFRT WNRAGHLLFG ELRRGSGSFV LFLKDGKLKL SLFQPGQSPR NVTAGAGLND GQWHSVSFSA KWSHMNVVVD DDTAVQPLVA VLIDSGDTYY FGGCLDNSSG SGCKSPLGGF QGCLRLITIG DKAVDPILVQ QGALGSFRDL QIDSCGITDR CLPSYCEHGG ECSQSWDTFS CDCLGTGYTG ETCHSSLYEQ SCEAHKHRGN PSGLYYIDAD GSGPLGPFLV YCNMTADAAW TVVQHGGPDA VTLRGAPSGH PRSAVSFAYA AGAGQLRSAV NLAERCEQRL ALRCGTARRP DSRDGTPLSW WVGRTNETHT SWGGSLPDAQ KCTCGLEGNC IDSQYYCNCD AGRNEWTSDT IVLSQKEHLP VTQIVMTDAG RPHSEAAYTL GPLLCRGDQS FWNSASFNTE TSYLHFPAFH GELTADVCFF FKTTVSSGVF MENLGITDFI RIELRAPTEV TFSFDVGNGP CEVTVQSPTP FNDNQWHHVR AERNVKGASL QVDQLPQKMQ PAPADGHVRL QLNSQLFIGG TATRQRGFLG CIRSLQLNGV ALDLEERATV TPGVEPGCAG HCSTYGHLCR NGGRCREKRR GVTCDCAFSA YDGPFCSNEI SAYFATGSSM TYHFQEHYTL SENSSSLVSS LHRDVTLTRE MITLSFRTTR TPSLLLYVSS FYEEYLSVIL ANNGSLQIRY KLDRHQNPDA FTFDFKNMAD GQLHQVKINR EEAVVMVEVN QSTKKQVILS SGTEFNAVKS LILGKVLEAA GADPDTRRAA TSGFTGCLSA VRFGRAAPLK AALRPSGPSR VTVRGHVAPM ARCAAGAASG SPARELAPRL AGGAGRSGPA DEGEPLVNAD RRDSAVIGGV IAVVIFILLC ITAIAIRIYQ QRKLRKENES KVSKKEEC
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