Equilibrative nucleoside transporter 3 (SLC29A3)

About Equilibrative nucleoside transporter 3

Equilibrative nucleoside transporter 3 (SLC29A3) is a protein from Homo sapiens identified by UniProt accession Q9BZD2, 475 residues long. MolForge cross-references it against 0 known binders and 283 disease associations.

Target properties

Protein name	Equilibrative nucleoside transporter 3
UniProt accession	Q9BZD2
Gene	SLC29A3
Organism	Homo sapiens
Length	475 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (283)

Diseases linked to this target (Open Targets).

H syndrome · score 0.84
neurodegenerative disease · score 0.44
lymphocyte count · score 0.42
dysosteosclerosis · score 0.38
Disorder of amino acid and other organic acid metabolism · score 0.37
acanthosis nigricans · score 0.33
myeloid white cell count · score 0.31
neuritic plaque measurement · score 0.31
leukocyte count · score 0.28
genetic disorder · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BZD2-F1	alphafold	PREDICTED	82.33	—

Amino-acid sequence (475 residues)

MAVVSEDDFQ HSSNSTYRTT SSSLRADQEA LLEKLLDRPP PGLQRPEDRF CGTYIIFFSL GIGSLLPWNF FITAKEYWMF KLRNSSSPAT GEDPEGSDIL NYFESYLAVA STVPSMLCLV ANFLLVNRVA VHIRVLASLT VILAIFMVIT ALVKVDTSSW TRGFFAVTIV CMVILSGAST VFSSSIYGMT GSFPMRNSQA LISGGAMGGT VSAVASLVDL AASSDVRNSA LAFFLTATVF LVLCMGLYLL LSRLEYARYY MRPVLAAHVF SGEEELPQDS LSAPSVASRF IDSHTPPLRP ILKKTASLGF CVTYVFFITS LIYPAICTNI ESLNKGSGSL WTTKFFIPLT TFLLYNFADL CGRQLTAWIQ VPGPNSKALP GFVLLRTCLI PLFVLCNYQP RVHLKTVVFQ SDVYPALLSS LLGLSNGYLS TLALLYGPKI VPRELAEATG VVMSFYVCLG LTLGSACSTL LVHLI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards