Kinetochore protein Nuf2 (NUF2)

About Kinetochore protein Nuf2

Kinetochore protein Nuf2 (NUF2) is a protein from Homo sapiens identified by UniProt accession Q9BZD4, 464 residues long. MolForge cross-references it against 0 known binders and 145 disease associations.

Target properties

Protein name	Kinetochore protein Nuf2
UniProt accession	Q9BZD4
Gene	NUF2
Organism	Homo sapiens
Length	464 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (145)

Diseases linked to this target (Open Targets).

Microcephaly · score 0.34
Short stature · score 0.34
neurodegenerative disease · score 0.20
testosterone measurement · score 0.16
urate measurement · score 0.16
heel bone mineral density · score 0.16
body height · score 0.16
prostate carcinoma · score 0.15
hypertension · score 0.15
bipolar disorder · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BZD4-F1	alphafold	PREDICTED	89.58	—

Amino-acid sequence (464 residues)

METLSFPRYN VAEIVIHIRN KILTGADGKN LTKNDLYPNP KPEVLHMIYM RALQIVYGIR LEHFYMMPVN SEVMYPHLME GFLPFSNLVT HLDSFLPICR VNDFETADIL CPKAKRTSRF LSGIINFIHF REACRETYME FLWQYKSSAD KMQQLNAAHQ EALMKLERLD SVPVEEQEEF KQLSDGIQEL QQSLNQDFHQ KTIVLQEGNS QKKSNISEKT KRLNELKLSV VSLKEIQESL KTKIVDSPEK LKNYKEKMKD TVQKLKNARQ EVVEKYEIYG DSVDCLPSCQ LEVQLYQKKI QDLSDNREKL ASILKESLNL EDQIESDESE LKKLKTEENS FKRLMIVKKE KLATAQFKIN KKHEDVKQYK RTVIEDCNKV QEKRGAVYER VTTINQEIQK IKLGIQQLKD AAEREKLKSQ EIFLNLKTAL EKYHDGIEKA AEDSYAKIDE KTAELKRKMF KMST

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards