About Transmembrane gamma-carboxyglutamic acid protein 3
Transmembrane gamma-carboxyglutamic acid protein 3 (PRRG3) is a protein
from Homo sapiens identified by UniProt accession
Q9BZD7, 231 residues long.
MolForge cross-references it against 0 known binders and
19 disease associations.
Target properties
| Protein name | Transmembrane gamma-carboxyglutamic acid protein 3 |
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| UniProt accession | Q9BZD7 |
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| Gene | PRRG3 |
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| Organism | Homo sapiens |
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| Length | 231 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (19)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.36
- body height · score 0.17
- bone disease · score 0.08
- cartilage disease · score 0.08
- carcinoma of liver and intrahepatic biliary tract · score 0.01
- Tetralogy of Fallot · score 0.01
- psoriasis · score 0.01
- glioblastoma multiforme · score 0.01
- atopic eczema · score 0.01
- invasive breast ductal carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BZD7-F1 | alphafold | PREDICTED | 63.79 | — |
Amino-acid sequence (231 residues)
MAVFLEAKDA HSVLKRFPRA NEFLEELRQG TIERECMEEI CSYEEVKEVF ENKEKTMEFW KGYPNAVYSV RDPSQSSDAM YVVVPLLGVA LLIVIALFII WRCQLQKATR HHPSYAQNRY LASRAGHTLP RVMVYRGTVH SQGEPSGHRE AANSPQVVLG PSRGGRTTVR LESTLYLPEL SLSRLSSTTP PPSYEEVTAP QESSSEEASV SYSDPPPKYE EIVAANPGAD K
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