Zinc finger protein GLIS2 (GLIS2)

About Zinc finger protein GLIS2

Zinc finger protein GLIS2 (GLIS2) is a protein from Homo sapiens identified by UniProt accession Q9BZE0, 524 residues long. MolForge cross-references it against 0 known binders and 265 disease associations.

Target properties

Protein name	Zinc finger protein GLIS2
UniProt accession	Q9BZE0
Gene	GLIS2
Organism	Homo sapiens
Length	524 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (265)

Diseases linked to this target (Open Targets).

nephronophthisis · score 0.66
Juvenile nephronophthisis · score 0.37
BMI-adjusted hip circumference · score 0.27
FEV/FVC ratio · score 0.25
body height · score 0.24
Nephronophthisis · score 0.24
alkaline phosphatase measurement · score 0.23
sitting height measurement · score 0.12
familial idiopathic steroid-resistant nephrotic syndrome · score 0.07
BMI-adjusted waist-hip ratio · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BZE0-F1	alphafold	PREDICTED	53.88	—

Amino-acid sequence (524 residues)

MHSLDEPLDL KLSITKLRAA REKRERTLGV VRPRALHREL GLVDDSPTPG SPGSPPSGFL LNSKFPEKVE GRFSAAPLVD LSLSPPSGLD SPNGSSSLSP ERQGNGDLPP VPSASDFQPL RYLDGVPSSF QFFLPLGSGG ALHLPASSFL TPPKDKCLSP DLPLPKQLVC RWAKCNQLFE LLQDLVDHVN DYHVKPEKDA GYCCHWEGCA RHGRGFNARY KMLIHIRTHT NEKPHRCPTC SKSFSRLENL KIHNRSHTGE KPYVCPYEGC NKRYSNSSDR FKHTRTHYVD KPYYCKMPGC HKRYTDPSSL RKHIKAHGHF VSHEQQELLQ LRPPPKPPLP APDGGPYVSG AQIIIPNPAA LFGGPGLPGL PLPLAPGPLD LSALACGNGG GSGGGGGMGP GLPGPVLPLN LAKNPLLPSP FGAGGLGLPV VSLLAGAAGG KAEGEKGRGS VPTRALGMEG HKTPLERTES SCSRPSPDGL PLLPGTVLDL STGVNSAASS PEALAPGWVV IPPGSVLLKP AVVN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards