tRNA pseudouridine(38/39) synthase (PUS3)

About tRNA pseudouridine(38/39) synthase

tRNA pseudouridine(38/39) synthase (PUS3) is a protein from Homo sapiens identified by UniProt accession Q9BZE2, 481 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.

Target properties

Protein name	tRNA pseudouridine(38/39) synthase
UniProt accession	Q9BZE2
Gene	PUS3
Organism	Homo sapiens
Length	481 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (48)

Diseases linked to this target (Open Targets).

severe growth deficiency-strabismus-extensive dermal melanocytosis-intellectual disability syndrome · score 0.71
hydrolethalus syndrome · score 0.45
Hydrolethalus · score 0.42
Intellectual disability · score 0.37
Microcephaly · score 0.37
Global developmental delay · score 0.37
microcephaly · score 0.37
neurodegenerative disease · score 0.37
genetic disorder · score 0.34
congenital heart disease · score 0.33

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BZE2-F1	alphafold	PREDICTED	83.65	—

Amino-acid sequence (481 residues)

MAYNDTDRNQ TEKLLKRVRE LEQEVQRLKK EQAKNKEDSN IRENSAGAGK TKRAFDFSAH GRRHVALRIA YMGWGYQGFA SQENTNNTIE EKLFEALTKT RLVESRQTSN YHRCGRTDKG VSAFGQVISL DLRSQFPRGR DSEDFNVKEE ANAAAEEIRY THILNRVLPP DIRILAWAPV EPSFSARFSC LERTYRYFFP RADLDIVTMD YAAQKYVGTH DFRNLCKMDV ANGVINFQRT ILSAQVQLVG QSPGEGRWQE PFQLCQFEVT GQAFLYHQVR CMMAILFLIG QGMEKPEIID ELLNIEKNPQ KPQYSMAVEF PLVLYDCKFE NVKWIYDQEA QEFNITHLQQ LWANHAVKTH MLYSMLQGLD TVPVPCGIGP KMDGMTEWGN VKPSVIKQTS AFVEGVKMRT YKPLMDRPKC QGLESRIQHF VRRGRIEHPH LFHEEETKAK RDCNDTLEEE NTNLETPTKR VCVDTEIKSI I

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards