About GTP-binding protein 4
GTP-binding protein 4 (GTPBP4) is a protein
from Homo sapiens identified by UniProt accession
Q9BZE4, 634 residues long.
MolForge cross-references it against 0 known binders and
89 disease associations.
Target properties
| Protein name | GTP-binding protein 4 |
|---|
| UniProt accession | Q9BZE4 |
|---|
| Gene | GTPBP4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 634 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (89)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.34
- testosterone measurement · score 0.18
- eosinophil count · score 0.12
- hepatocellular carcinoma · score 0.10
- prostate carcinoma · score 0.09
- serum urea measurement · score 0.08
- neoplasm · score 0.08
- creatinine measurement · score 0.08
- Blackfan-Diamond anemia · score 0.07
- erythrocyte count · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BZE4-F1 | alphafold | PREDICTED | 83.19 | — |
Amino-acid sequence (634 residues)
MAHYNFKKIT VVPSAKDFID LTLSKTQRKT PTVIHKHYQI HRIRHFYMRK VKFTQQNYHD RLSQILTDFP KLDDIHPFYA DLMNILYDKD HYKLALGQIN IAKNLVDNVA KDYVRLMKYG DSLYRCKQLK RAALGRMCTV IKRQKQSLEY LEQVRQHLSR LPTIDPNTRT LLLCGYPNVG KSSFINKVTR ADVDVQPYAF TTKSLFVGHM DYKYLRWQVV DTPGILDHPL EDRNTIEMQA ITALAHLRAA VLYVMDLSEQ CGHGLREQLE LFQNIRPLFI NKPLIVVANK CDVKRIAELS EDDQKIFTDL QSEGFPVIET STLTEEGVIK VKTEACDRLL AHRVETKMKG NKVNEVLNRL HLAIPTRRDD KERPPFIPEG VVARRKRMET EESRKKRERD LELEMGDDYI LDLQKYWDLM NLSEKHDKIP EIWEGHNIAD YIDPAIMKKL EELEKEEELR TAAGEYDSVS ESEDEEMLEI RQLAKQIREK KKLKILESKE KNTQGPRMPR TAKKVQRTVL EKEMRSLGVD MDDKDDAHYA VQARRSRSIT RKRKREDSAP PSSVARSGSC SRTPRDVSGL RDVKMVKKAK TMMKNAQKKM NRLGKKGEAD RHVFDMKPKH LLSGKRKAGK KDRR
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