About Tether containing UBX domain for GLUT4
Tether containing UBX domain for GLUT4 (ASPSCR1) is a protein
from Homo sapiens identified by UniProt accession
Q9BZE9, 553 residues long.
MolForge cross-references it against 0 known binders and
174 disease associations.
Target properties
| Protein name | Tether containing UBX domain for GLUT4 |
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| UniProt accession | Q9BZE9 |
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| Gene | ASPSCR1 |
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| Organism | Homo sapiens |
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| Length | 553 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (174)
Diseases linked to this target (Open Targets).
- alveolar soft part sarcoma · score 0.38
- renal carcinoma · score 0.37
- Paraganglioma · score 0.37
- chordoma · score 0.37
- cutaneous melanoma · score 0.37
- undifferentiated pleomorphic sarcoma · score 0.37
- alveolar rhabdomyosarcoma · score 0.37
- Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions · score 0.29
- vital capacity · score 0.29
- Granular Cell Tumor · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BZE9-F1 | alphafold | PREDICTED | 71.21 | — |
Amino-acid sequence (553 residues)
MAAPAGGGGS AVSVLAPNGR RHTVKVTPST VLLQVLEDTC RRQDFNPCEY DLKFQRSVLD LSLQWRFANL PNNAKLEMVP ASRSREGPEN MVRIALQLDD GSRLQDSFCS GQTLWELLSH FPQIRECLQH PGGATPVCVY TRDEVTGEAA LRGTTLQSLG LTGGSATIRF VMKCYDPVGK TPGSLGSSAS AGQAAASAPL PLESGELSRG DLSRPEDADT SGPCCEHTQE KQSTRAPAAA PFVPFSGGGQ RLGGPPGPTR PLTSSSAKLP KSLSSPGGPS KPKKSKSGQD PQQEQEQERE RDPQQEQERE RPVDREPVDR EPVVCHPDLE ERLQAWPAEL PDEFFELTVD DVRRRLAQLK SERKRLEEAP LVTKAFREAQ IKEKLERYPK VALRVLFPDR YVLQGFFRPS ETVGDLRDFV RSHLGNPELS FYLFITPPKT VLDDHTQTLF QANLFPAALV HLGAEEPAGV YLEPGLLEHA ISPSAADVLV ARYMSRAAGS PSPLPAPDPA PKSEPAAEEG ALVPPEPIPG TAQPVKRSLG KVPKWLKLPA SKR
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