Testicular acid phosphatase (ACP4)

About Testicular acid phosphatase

Testicular acid phosphatase (ACP4) is a protein from Homo sapiens identified by UniProt accession Q9BZG2, 426 residues long. MolForge cross-references it against 0 known binders and 61 disease associations.

Target properties

Protein name	Testicular acid phosphatase
UniProt accession	Q9BZG2
Gene	ACP4
Organism	Homo sapiens
Length	426 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (61)

Diseases linked to this target (Open Targets).

Hypoplastic amelogenesis imperfecta · score 0.75
amelogenesis imperfecta, type ij · score 0.73
amelogenesis imperfecta · score 0.17
Hypomaturation amelogenesis imperfecta · score 0.11
cystatin C measurement · score 0.08
amelogenesis imperfecta type 3B · score 0.07
amelogenesis imperfecta, IIa 1K · score 0.07
amelogenesis imperfecta hypomaturation type 2A4 · score 0.07
dentin dysplasia type II · score 0.07
dentinogenesis imperfecta type 3 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BZG2-F1	alphafold	PREDICTED	87.61	—

Amino-acid sequence (426 residues)

MAGLGFWGHP AGPLLLLLLL VLPPRALPEG PLVFVALVFR HGDRAPLASY PMDPHKEVAS TLWPRGLGQL TTEGVRQQLE LGRFLRSRYE AFLSPEYRRE EVYIRSTDFD RTLESAQANL AGLFPEAAPG SPEARWRPIP VHTVPVAEDK LLRFPMRSCP RYHELLREAT EAAEYQEALE GWTGFLSRLE NFTGLSLVGE PLRRAWKVLD TLMCQQAHGL PLPAWASPDV LRTLAQISAL DIGAHVGPPR AAEKAQLTGG ILLNAILANF SRVQRLGLPL KMVMYSAHDS TLLALQGALG LYDGHTPPYA ACLGFEFRKH LGNPAKDGGN VTVSLFYRND SAHLPLPLSL PGCPAPCPLG RFYQLTAPAR PPAHGVSCHG PYEAAIPPAP VVPLLAGAVA VLVALSLGLG LLAWRPGCLR ALGGPV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards