About Iroquois-class homeodomain protein IRX-2
Iroquois-class homeodomain protein IRX-2 (IRX2) is a protein
from Homo sapiens identified by UniProt accession
Q9BZI1, 471 residues long.
MolForge cross-references it against 0 known binders and
85 disease associations.
Target properties
| Protein name | Iroquois-class homeodomain protein IRX-2 |
|---|
| UniProt accession | Q9BZI1 |
|---|
| Gene | IRX2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 471 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (85)
Diseases linked to this target (Open Targets).
- protein measurement · score 0.30
- PHF-tau measurement · score 0.27
- ulcerative colitis · score 0.26
- brain volume measurement · score 0.26
- neuroimaging measurement · score 0.26
- retinal layer thickness measurement · score 0.24
- retinal nerve fibre layer thickness measurement · score 0.24
- macula measurement · score 0.24
- ganglion cell inner plexiform layer thickness measurement · score 0.24
- mathematical ability · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BZI1-F1 | alphafold | PREDICTED | 54.27 | — |
Amino-acid sequence (471 residues)
MSYPQGYLYQ APGSLALYSC PAYGASALAA PRSEELARSA SGSAFSPYPG SAAFTAQAAT GFGSPLQYSA DAAAAAAGFP SYMGAPYDAH TTGMTGAISY HPYGSAAYPY QLNDPAYRKN ATRDATATLK AWLNEHRKNP YPTKGEKIML AIITKMTLTQ VSTWFANARR RLKKENKMTW APRNKSEDED EDEGDATRSK DESPDKAQEG TETSAEDEGI SLHVDSLTDH SCSAESDGEK LPCRAGDPLC ESGSECKDKY DDLEDDEDDD EEGERGLAPP KPVTSSPLTG LEAPLLSPPP EAAPRGGRKT PQGSRTSPGA PPPASKPKLW SLAEIATSDL KQPSLGPGCG PPGLPAAAAP ASTGAPPGGS PYPASPLLGR PLYYTSPFYG NYTNYGNLNA ALQGQGLLRY NSAAAAPGEA LHTAPKAASD AGKAGAHPLE SHYRSPGGGY EPKKDASEGC TVVGGGVQPY L
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