Small integral membrane protein 3 (SMIM3)

About Small integral membrane protein 3

Small integral membrane protein 3 (SMIM3) is a protein from Homo sapiens identified by UniProt accession Q9BZL3, 60 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.

Target properties

Protein name	Small integral membrane protein 3
UniProt accession	Q9BZL3
Gene	SMIM3
Organism	Homo sapiens
Length	60 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (33)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.41
acute myeloid leukemia · score 0.07
inflammatory bowel disease · score 0.05
Crohn's disease · score 0.05
ulcerative colitis · score 0.04
rheumatoid arthritis · score 0.03
cancer · score 0.03
neoplasm · score 0.02
glioblastoma multiforme · score 0.02
ankylosing spondylitis · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BZL3-F1	alphafold	PREDICTED	76.30	—

Amino-acid sequence (60 residues)

MDAVSQVPME VVLPKHILDI WVIVLIILAT IVIMTSLLLC PATAVIIYRM RTHPILSGAV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards