About GS homeobox 2
GS homeobox 2 (GSX2) is a protein
from Homo sapiens identified by UniProt accession
Q9BZM3, 304 residues long.
MolForge cross-references it against 0 known binders and
58 disease associations.
Target properties
| Protein name | GS homeobox 2 |
|---|
| UniProt accession | Q9BZM3 |
|---|
| Gene | GSX2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 304 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (58)
Diseases linked to this target (Open Targets).
- diencephalic-mesencephalic junction dysplasia · score 0.53
- neurodegenerative disease · score 0.52
- cup-to-disc ratio measurement · score 0.36
- schizophrenia · score 0.30
- diet measurement · score 0.28
- optic disc size measurement · score 0.25
- lymphocyte count · score 0.25
- leukocyte count · score 0.24
- pulse pressure measurement · score 0.20
- Intellectual disability · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BZM3-F1 | alphafold | PREDICTED | 59.23 | — |
Amino-acid sequence (304 residues)
MSRSFYVDSL IIKDTSRPAP SLPEPHPGPD FFIPLGMPPP LVMSVSGPGC PSRKSGAFCV CPLCVTSHLH SSRGSVGAGS GGAGAGVTGA GGSGVAGAAG ALPLLKGQFS SAPGDAQFCP RVNHAHHHHH PPQHHHHHHQ PQQPGSAAAA AAAAAAAAAA AALGHPQHHA PVCTATTYNV ADPRRFHCLT MGGSDASQVP NGKRMRTAFT STQLLELERE FSSNMYLSRL RRIEIATYLN LSEKQVKIWF QNRRVKHKKE GKGTQRNSHA GCKCVGSQVH YARSEDEDSL SPASANDDKE ISPL
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