About Testicular spindle-associated protein SHCBP1L
Testicular spindle-associated protein SHCBP1L (SHCBP1L) is a protein
from Homo sapiens identified by UniProt accession
Q9BZQ2, 653 residues long.
MolForge cross-references it against 0 known binders and
86 disease associations.
Target properties
| Protein name | Testicular spindle-associated protein SHCBP1L |
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| UniProt accession | Q9BZQ2 |
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| Gene | SHCBP1L |
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| Organism | Homo sapiens |
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| Length | 653 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (86)
Diseases linked to this target (Open Targets).
- prostate cancer · score 0.11
- prostate carcinoma · score 0.11
- Familial prostate cancer · score 0.11
- azoospermia · score 0.08
- creatinine measurement · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- partial chromosome Y deletion · score 0.07
- protein measurement · score 0.06
- spermatogenic failure 25 · score 0.06
- congenital bilateral absence of vas deferens · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BZQ2-F1 | alphafold | PREDICTED | 76.80 | — |
Amino-acid sequence (653 residues)
MASGSKASVP ADSFRTISPD RRGEKSASAV SGDTAAATTL KGTAIPVRSV VASPRPVKGK AGRETARLRL QRLPAAQAED TGEAAAAAAE EPLLPVPEDE EEAQPLPPVC VSRMRGMWRD EKVSLYCDEV LQDCKAEDAD EVMGKYLSEK LKLKDKWLGV WKTNPSVFFV KYEEASIPFV GILVEVTCEP YQDSSSRFKV TVSVAEPFSS NIANIPRDLV DEILEELEHS VPLLEVYPVE GQDTDIHVIA LALEVVRFFY DFLWRDWDDE ESCENYTALI EERINLWCDI QDGTIPGPIA QRFKKTLEKY KNKRVELIEY QSNIKEDPSA AEAVECWKKY YEIVMLCGLL KMWEDLRLRV HGPFFPRILR RRKGKREFGK TITHIVAKMM TTEMIKDLSS DTLLQQHGDL DLALDNCYSG DTVIIFPGEY QAANLALLTD DIIIKGVGKR EEIMITSEPS RDSFVVSKAD NVKLMHLSLI QQGTVDGIVV VESGHMTLEN CILKCEGTGV CVLTGAALTI TDSEITGAQG AGVELYPGSI AILERNEIHH CNNLRTSNSS KSTLGGVNMK VLPAPKLKMT NNHIYSNKGY GVSILQPMEQ FFIVAEEALN KRASSGDKKD DKMLFKVMQN LNLEMNNNKI EANVKGDIRI VTS
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