Apoptosis facilitator Bcl-2-like protein 14 (BCL2L14)

About Apoptosis facilitator Bcl-2-like protein 14

Apoptosis facilitator Bcl-2-like protein 14 (BCL2L14) is a protein from Homo sapiens identified by UniProt accession Q9BZR8, 327 residues long. MolForge cross-references it against 0 known binders and 74 disease associations.

Target properties

Protein name	Apoptosis facilitator Bcl-2-like protein 14
UniProt accession	Q9BZR8
Gene	BCL2L14
Organism	Homo sapiens
Length	327 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (74)

Diseases linked to this target (Open Targets).

creatinine measurement · score 0.43
heel bone mineral density · score 0.41
calcium measurement · score 0.40
glomerular filtration rate · score 0.39
blood phosphate measurement · score 0.32
serum urea measurement · score 0.32
cystatin C measurement · score 0.32
bone density · score 0.28
balding measurement · score 0.28
breast adenocarcinoma · score 0.25

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BZR8-F1	alphafold	PREDICTED	62.38	—

Amino-acid sequence (327 residues)

MCSTSGCDLE EIPLDDDDLN TIEFKILAYY TRHHVFKSTP ALFSPKLLRT RSLSQRGLGN CSANESWTEV SWPCRNSQSS EKAINLGKKK SSWKAFFGVV EKEDSQSTPA KVSAQGQRTL EYQDSHSQQW SRCLSNVEQC LEHEAVDPKV ISIANRVAEI VYSWPPPQAT QAGGFKSKEI FVTEGLSFQL QGHVPVASSS KKDEEEQILA KIVELLKYSG DQLERKLKKD KALMGHFQDG LSYSVFKTIT DQVLMGVDPR GESEVKAQGF KAALVIDVTA KLTAIDNHPM NRVLGFGTKY LKENFSPWIQ QHGGWEKILG ISHEEVD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards