About E3 ubiquitin-protein ligase TRIM8
E3 ubiquitin-protein ligase TRIM8 (TRIM8) is a protein
from Homo sapiens identified by UniProt accession
Q9BZR9, 551 residues long.
MolForge cross-references it against 0 known binders and
203 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase TRIM8 |
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| UniProt accession | Q9BZR9 |
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| Gene | TRIM8 |
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| Organism | Homo sapiens |
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| Length | 551 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (203)
Diseases linked to this target (Open Targets).
- focal segmental glomerulosclerosis and neurodevelopmental syndrome · score 0.73
- Seizure · score 0.60
- nephrotic syndrome · score 0.50
- epilepsy · score 0.50
- Global developmental delay · score 0.46
- Intellectual disability · score 0.46
- genetic disorder · score 0.41
- focal segmental glomerulosclerosis · score 0.40
- Neurodevelopmental delay · score 0.40
- Neurodevelopmental disorder · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BZR9-F1 | alphafold | PREDICTED | 71.03 | — |
Amino-acid sequence (551 residues)
MAENWKNCFE EELICPICLH VFVEPVQLPC KHNFCRGCIG EAWAKDSGLV RCPECNQAYN QKPGLEKNLK LTNIVEKFNA LHVEKPPAAL HCVFCRRGPP LPAQKVCLRC EAPCCQSHVQ THLQQPSTAR GHLLVEADDV RAWSCPQHNA YRLYHCEAEQ VAVCQYCCYY SGAHQGHSVC DVEIRRNEIR KMLMKQQDRL EEREQDIEDQ LYKLESDKRL VEEKVNQLKE EVRLQYEKLH QLLDEDLRQT VEVLDKAQAK FCSENAAQAL HLGERMQEAK KLLGSLQLLF DKTEDVSFMK NTKSVKILMD RTQTCTSSSL SPTKIGHLNS KLFLNEVAKK EKQLRKMLEG PFSTPVPFLQ SVPLYPCGVS SSGAEKRKHS TAFPEASFLE TSSGPVGGQY GAAGTASGEG QSGQPLGPCS STQHLVALPG GAQPVHSSPV FPPSQYPNGS AAQQPMLPQY GGRKILVCSV DNCYCSSVAN HGGHQPYPRS GHFPWTVPSQ EYSHPLPPTP SVPQSLPSLA VRDWLDASQQ PGHQDFYRVY GQPSTKHYVT S
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