About Thiamine transporter 2
Thiamine transporter 2 (SLC19A3) is a protein
from Homo sapiens identified by UniProt accession
Q9BZV2, 496 residues long.
MolForge cross-references it against 0 known binders and
109 disease associations.
Target properties
| Protein name | Thiamine transporter 2 |
|---|
| UniProt accession | Q9BZV2 |
|---|
| Gene | SLC19A3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 496 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (109)
Diseases linked to this target (Open Targets).
- biotin-responsive basal ganglia disease · score 0.82
- Thiamine-responsive encephalopathy · score 0.69
- genetic disorder · score 0.49
- Leigh syndrome · score 0.37
- Dystonia · score 0.37
- Infantile spams - psychomotor retardation - progressive brain atrophy - basal ganglia disease · score 0.37
- neurodegenerative disease · score 0.35
- high density lipoprotein cholesterol measurement · score 0.31
- metabolite measurement · score 0.25
- apolipoprotein A 1 measurement · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BZV2-F1 | alphafold | PREDICTED | 81.59 | — |
Amino-acid sequence (496 residues)
MDCYRTSLSS SWIYPTVILC LFGFFSMMRP SEPFLIPYLS GPDKNLTSAE ITNEIFPVWT YSYLVLLLPV FVLTDYVRYK PVIILQGISF IITWLLLLFG QGVKTMQVVE FFYGMVTAAE VAYYAYIYSV VSPEHYQRVS GYCRSVTLAA YTAGSVLAQL LVSLANMSYF YLNVISLASV SVAFLFSLFL PMPKKSMFFH AKPSREIKKS SSVNPVLEET HEGEAPGCEE QKPTSEILST SGKLNKGQLN SLKPSNVTVD VFVQWFQDLK ECYSSKRLFY WSLWWAFATA GFNQVLNYVQ ILWDYKAPSQ DSSIYNGAVE AIATFGGAVA AFAVGYVKVN WDLLGELALV VFSVVNAGSL FLMHYTANIW ACYAGYLIFK SSYMLLITIA VFQIAVNLNV ERYALVFGIN TFIALVIQTI MTVIVVDQRG LNLPVSIQFL VYGSYFAVIA GIFLMRSMYI TYSTKSQKDV QSPAPSENPD VSHPEEESNI IMSTKL
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