Transmembrane 6 superfamily member 2 (TM6SF2)

About Transmembrane 6 superfamily member 2

Transmembrane 6 superfamily member 2 (TM6SF2) is a protein from Homo sapiens identified by UniProt accession Q9BZW4, 377 residues long. MolForge cross-references it against 0 known binders and 239 disease associations.

Target properties

Protein name	Transmembrane 6 superfamily member 2
UniProt accession	Q9BZW4
Gene	TM6SF2
Organism	Homo sapiens
Length	377 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (239)

Diseases linked to this target (Open Targets).

triglyceride measurement · score 0.45
total cholesterol measurement · score 0.43
low density lipoprotein cholesterol measurement · score 0.42
serum alanine aminotransferase measurement · score 0.42
alkaline phosphatase measurement · score 0.40
vitamin D measurement · score 0.39
bilirubin measurement · score 0.38
aspartate aminotransferase measurement · score 0.37
type 2 diabetes mellitus · score 0.37
Hypercholesterolemia · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BZW4-F1	alphafold	PREDICTED	90.99	—

Amino-acid sequence (377 residues)

MDIPPLAGKI AALSLSALPV SYALNHVSAL SHPLWVALMS ALILGLLFVA VYSLSHGEVS YDPLYAVFAV FAFTSVVDLI IALQEDSYVV GFMEFYTKEG EPYLRTAHGV FICYWDGTVH YLLYLAMAGA ICRRKRYRNF GLYWLGSFAM SILVFLTGNI LGKYSSEIRP AFFLTIPYLL VPCWAGMKVF SQPRALTRCT ANMVQEEQRK GLLQRPADLA LVIYLILAGF FTLFRGLVVL DCPTDACFVY IYQYEPYLRD PVAYPKVQML MYMFYVLPFC GLAAYALTFP GCSWLPDWAL VFAGGIGQAQ FSHMGASMHL RTPFTYRVPE DTWGCFFVCN LLYALGPHLL AYRCLQWPAF FHQPPPSDPL ALHKKQH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards