About Sialoadhesin
Sialoadhesin (SIGLEC1) is a protein
from Homo sapiens identified by UniProt accession
Q9BZZ2, 1709 residues long.
MolForge cross-references it against 0 known binders and
383 disease associations.
Target properties
| Protein name | Sialoadhesin |
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| UniProt accession | Q9BZZ2 |
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| Gene | SIGLEC1 |
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| Organism | Homo sapiens |
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| Length | 1709 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (383)
Diseases linked to this target (Open Targets).
- serum gamma-glutamyl transferase measurement · score 0.64
- blood protein measurement · score 0.45
- neurodegenerative disease · score 0.42
- platelet count · score 0.39
- lymphocyte count · score 0.36
- leukocyte count · score 0.35
- reticulocyte count · score 0.31
- serum IgM measurement · score 0.29
- galectin-3-binding protein measurement · score 0.28
- interleukin 6 receptor subunit beta measurement · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9BZZ2-F1 | alphafold | PREDICTED | 76.61 | — |
Amino-acid sequence (1709 residues)
MGFLPKLLLL ASFFPAGQAS WGVSSPQDVQ GVKGSCLLIP CIFSFPADVE VPDGITAIWY YDYSGQRQVV SHSADPKLVE ARFRGRTEFM GNPEHRVCNL LLKDLQPEDS GSYNFRFEIS EVNRWSDVKG TLVTVTEEPR VPTIASPVEL LEGTEVDFNC STPYVCLQEQ VRLQWQGQDP ARSVTFNSQK FEPTGVGHLE TLHMAMSWQD HGRILRCQLS VANHRAQSEI HLQVKYAPKG VKILLSPSGR NILPGELVTL TCQVNSSYPA VSSIKWLKDG VRLQTKTGVL HLPQAAWSDA GVYTCQAENG VGSLVSPPIS LHIFMAEVQV SPAGPILENQ TVTLVCNTPN EAPSDLRYSW YKNHVLLEDA HSHTLRLHLA TRADTGFYFC EVQNVHGSER SGPVSVVVNH PPLTPVLTAF LETQAGLVGI LHCSVVSEPL ATLVLSHGGH ILASTSGDSD HSPRFSGTSG PNSLRLEIRD LEETDSGEYK CSATNSLGNA TSTLDFHANA ARLLISPAAE VVEGQAVTLS CRSGLSPTPD ARFSWYLNGA LLHEGPGSSL LLPAASSTDA GSYHCRARDG HSASGPSSPA VLTVLYPPRQ PTFTTRLDLD AAGAGAGRRG LLLCRVDSDP PARLQLLHKD RVVATSLPSG GGCSTCGGCS PRMKVTKAPN LLRVEIHNPL LEEEGLYLCE ASNALGNAST SATFNGQATV LAIAPSHTLQ EGTEANLTCN VSREAAGSPA NFSWFRNGVL WAQGPLETVT LLPVARTDAA LYACRILTEA GAQLSTPVLL SVLYPPDRPK LSALLDMGQG HMALFICTVD SRPLALLALF HGEHLLATSL GPQVPSHGRF QAKAEANSLK LEVRELGLGD SGSYRCEATN VLGSSNTSLF FQVRGAWVQV SPSPELQEGQ AVVLSCQVHT GVPEGTSYRW YRDGQPLQES TSATLRFAAI TLTQAGAYHC QAQAPGSATT SLAAPISLHV SYAPRHVTLT TLMDTGPGRL GLLLCRVDSD PPAQLRLLHG DRLVASTLQG VGGPEGSSPR LHVAVAPNTL RLEIHGAMLE DEGVYICEAS NTLGQASASA DFDAQAVNVQ VWPGATVREG QLVNLTCLVW TTHPAQLTYT WYQDGQQRLD AHSIPLPNVT VRDATSYRCG VGPPGRAPRL SRPITLDVLY APRNLRLTYL LESHGGQLAL VLCTVDSRPP AQLALSHAGR LLASSTAASV PNTLRLELRG PQPRDEGFYS CSARSPLGQA NTSLELRLEG VRVILAPEAA VPEGAPITVT CADPAAHAPT LYTWYHNGRW LQEGPAASLS FLVATRAHAG AYSCQAQDAQ GTRSSRPAAL QVLYAPQDAV LSSFRDSRAR SMAVIQCTVD SEPPAELALS HDGKVLATSS GVHSLASGTG HVQVARNALR LQVQDVPAGD DTYVCTAQNL LGSISTIGRL QVEGARVVAE PGLDVPEGAA LNLSCRLLGG PGPVGNSTFA WFWNDRRLHA EPVPTLAFTH VARAQAGMYH CLAELPTGAA ASAPVMLRVL YPPKTPTMMV FVEPEGGLRG ILDCRVDSEP LASLTLHLGS RLVASSQPQG APAEPHIHVL ASPNALRVDI EALRPSDQGE YICSASNVLG SASTSTYFGV RALHRLHQFQ QLLWVLGLLV GLLLLLLGLG ACYTWRRRRV CKQSMGENSV EMAFQKETTQ LIDPDAATCE TSTCAPPLG
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