Apoptosis inhibitor 5 (API5)

About Apoptosis inhibitor 5

Apoptosis inhibitor 5 (API5) is a protein from Homo sapiens identified by UniProt accession Q9BZZ5, 524 residues long. MolForge cross-references it against 0 known binders and 70 disease associations.

Target properties

Protein name	Apoptosis inhibitor 5
UniProt accession	Q9BZZ5
Gene	API5
Organism	Homo sapiens
Length	524 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (70)

Diseases linked to this target (Open Targets).

refractive error · score 0.27
PHF-tau measurement · score 0.19
drug use measurement · score 0.19
Abnormality of refraction · score 0.18
self reported educational attainment · score 0.17
monocyte percentage of leukocytes · score 0.16
mathematical ability · score 0.16
neutrophil count · score 0.14
neutrophil percentage of leukocytes · score 0.14
adolescent idiopathic scoliosis · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9BZZ5-F1	alphafold	PREDICTED	84.63	—

Amino-acid sequence (524 residues)

MPTVEELYRN YGILADATEQ VGQHKDAYQV ILDGVKGGTK EKRLAAQFIP KFFKHFPELA DSAINAQLDL CEDEDVSIRR QAIKELPQFA TGENLPRVAD ILTQLLQTDD SAEFNLVNNA LLSIFKMDAK GTLGGLFSQI LQGEDIVRER AIKFLSTKLK TLPDEVLTKE VEELILTESK KVLEDVTGEE FVLFMKILSG LKSLQTVSGR QQLVELVAEQ ADLEQTFNPS DPDCVDRLLQ CTRQAVPLFS KNVHSTRFVT YFCEQVLPNL GTLTTPVEGL DIQLEVLKLL AEMSSFCGDM EKLETNLRKL FDKLLEYMPL PPEEAENGEN AGNEEPKLQF SYVECLLYSF HQLGRKLPDF LTAKLNAEKL KDFKIRLQYF ARGLQVYIRQ LRLALQGKTG EALKTEENKI KVVALKITNN INVLIKDLFH IPPSYKSTVT LSWKPVQKVE IGQKRASEDT TSGSPPKKSS AGPKRDARQI YNPPSGKYSS NLGNFNYEQR GAFRGSRGGR GWGTRGNRSR GRLY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards