About Protein sprouty homolog 4
Protein sprouty homolog 4 (SPRY4) is a protein
from Homo sapiens identified by UniProt accession
Q9C004, 299 residues long.
MolForge cross-references it against 0 known binders and
357 disease associations.
Target properties
| Protein name | Protein sprouty homolog 4 |
|---|
| UniProt accession | Q9C004 |
|---|
| Gene | SPRY4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 299 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (357)
Diseases linked to this target (Open Targets).
- Kallmann syndrome · score 0.57
- neurodegenerative disease · score 0.53
- testicular carcinoma · score 0.43
- lean body mass · score 0.40
- hypogonadotropic hypogonadism · score 0.40
- age at menopause · score 0.38
- Testicular Germ Cell Tumor · score 0.37
- fat body mass · score 0.36
- appendicular lean mass · score 0.36
- body weight · score 0.36
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9C004-F1 | alphafold | PREDICTED | 60.93 | — |
Amino-acid sequence (299 residues)
MEPPIPQSAP LTPNSVMVQP LLDSRMSHSR LQHPLTILPI DQVKTSHVEN DYIDNPSLAL TTGPKRTRGG APELAPTPAR CDQDVTHHWI SFSGRPSSVS SSSSTSSDQR LLDHMAPPPV ADQASPRAVR IQPKVVHCQP LDLKGPAVPP ELDKHFLLCE ACGKCKCKEC ASPRTLPSCW VCNQECLCSA QTLVNYGTCM CLVQGIFYHC TNEDDEGSCA DHPCSCSRSN CCARWSFMGA LSVVLPCLLC YLPATGCVKL AQRGYDRLRR PGCRCKHTNS VICKAASGDA KTSRPDKPF
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