cAMP-dependent protein kinase inhibitor beta (PKIB)

About cAMP-dependent protein kinase inhibitor beta

cAMP-dependent protein kinase inhibitor beta (PKIB) is a protein from Homo sapiens identified by UniProt accession Q9C010, 78 residues long. MolForge cross-references it against 0 known binders and 83 disease associations.

Target properties

Protein name	cAMP-dependent protein kinase inhibitor beta
UniProt accession	Q9C010
Gene	PKIB
Organism	Homo sapiens
Length	78 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (83)

Diseases linked to this target (Open Targets).

mean corpuscular volume · score 0.44
monocyte count · score 0.38
mean corpuscular hemoglobin · score 0.37
mean reticulocyte volume · score 0.37
leukocyte count · score 0.36
erythrocyte count · score 0.35
mean corpuscular hemoglobin concentration · score 0.34
lymphocyte count · score 0.34
neutrophil count · score 0.32
platelet count · score 0.31

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9C010-F1	alphafold	PREDICTED	64.08	—

Amino-acid sequence (78 residues)

MRTDSSKMTD VESGVANFAS SARAGRRNAL PDIQSSAATD GTSDLPLKLE ALSVKEDAKE KDEKTTQDQL EKPQNEEK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards